NF 110 | Tocris Bioscience 2548 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NF 110

catalog :

2548

quantity :

10 mg (also 50 mg)

price :

217 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Chandra N, Frängsmyr L, Arnberg N. Decoy Receptor Interactions as Novel Drug Targets against EKC-Causing Human Adenovirus. Viruses. 2019;11: pubmed publisher
Dosch M, Zindel J, Jebbawi F, Melin N, Sánchez Taltavull D, Stroka D, et al. Connexin-43-dependent ATP release mediates macrophage activation during sepsis. elife. 2019;8: pubmed publisher
Nishimura Y, McLaughlin N, Pan J, Goldstein S, Hafenstein S, Shimizu H, et al. The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate. PLoS Pathog. 2015;11:e1005184 pubmed publisher

product information

brand :

Tocris

master code :

2548

SKU :

2548/10

product name :

NF 110

description :

Potent P2X3 antagonist

target :

P2X Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

1096.9

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

High affinity P2X3 receptor antagonist (Ki values are 36, 82 and 4144 nM for P2X3, P2X1 and P2X2 recombinant receptors respectively). Shows no activity at P2Y1, P2Y2 and P2Y11 receptors (IC50 10 u M). Potently inhibits , -meATP-evoked desensitizing currents in rat DRG neurons (IC50 = 527 nM). Shows antitumor activity against several tumor types.

catalog number base :

2548

product keywords :

Potent P2X3 antagonists Receptors Purinergic purinoceptors NF110 P2X Receptors 2548,

extended description :

Potent P2X3 antagonist

chemical name text :

4,4 ,4 ,4 -[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonic acid tetrasodium salt

formula :

C 41 H 28 N 6 Na 4 O 17 S 4

formula text :

C41H28N6Na4O17S4

cas num :

111150-22-2

2020 USD :

210

2021 USD :

217 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage