NF 110 | Tocris Bioscience 2548/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NF 110

catalog :

2548/10

quantity :

10 mg (also 50 mg)

price :

269 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Su L, Bryan N, Battista S, Freitas J, Garabedian A, D Alessio F, et al. Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. Sci Rep. 2020;10:18850 pubmed publisher
Chandra N, Frängsmyr L, Arnberg N. Decoy Receptor Interactions as Novel Drug Targets against EKC-Causing Human Adenovirus. Viruses. 2019;11: pubmed publisher
Dosch M, Zindel J, Jebbawi F, Melin N, Sánchez Taltavull D, Stroka D, et al. Connexin-43-dependent ATP release mediates macrophage activation during sepsis. elife. 2019;8: pubmed publisher
Nishimura Y, McLaughlin N, Pan J, Goldstein S, Hafenstein S, Shimizu H, et al. The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate. PLoS Pathog. 2015;11:e1005184 pubmed publisher

image

image 1 :

Cat.No. 2548 - NF 110 C41H28N6Na4O17S4 CAS No. 111150-22-2

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

2548

SKU :

2548/10

product name :

NF 110

Description :

Potent P2X3 antagonist

target :

P2X Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

90%

observed molecular weight :

1096.9

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NF 110 is a high affinity P2X3 receptor antagonist (Ki values are 36, 82 and 4144 nM for P2X3, P2X1 and P2X2 recombinant receptors respectively). Shows no activity at P2Y1, P2Y2 and P2Y11 receptors (IC50 10 u M). Potently inhibits , -meATP-evoked desensitizing currents in rat DRG neurons (IC50 = 527 nM). Shows antitumor activity against several tumor types. Also inhibits DNA-binding activity of HMGA2 (IC50 = 0.87 M). . This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.

extended description :

Potent P2X3 antagonist

chemical name text :

4,4 ,4 ,4 -[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonic acid tetrasodium salt

formula :

C 41 H 28 N 6 Na 4 O 17 S 4

formula text :

C41H28N6Na4O17S4

cas num :

111150-22-2

USD :

269 USD

product details :

Potent P2X3 antagonist

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage