6-Hydroxydopamine hydrobromide | Tocris Bioscience 2547 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6-Hydroxydopamine hydrobromide

catalog :

2547

quantity :

50 mg

price :

86 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
McIver E, Atherton J, Chu H, Cosgrove K, Kondapalli J, Wokosin D, et al. Maladaptive Downregulation of Autonomous Subthalamic Nucleus Activity following the Loss of Midbrain Dopamine Neurons. Cell Rep. 2019;28:992-1002.e4 pubmed publisher
Fan S, Chang Y, Chen C, Wang W, Pan M, Chen W, et al. External light activates hair follicle stem cells through eyes via an ipRGC-SCN-sympathetic neural pathway. Proc Natl Acad Sci U S A. 2018;115:E6880-E6889 pubmed publisher
Chotibut T, Meadows S, Kasanga E, McInnis T, Cantu M, Bishop C, et al. Ceftriaxone reduces L-dopa-induced dyskinesia severity in 6-hydroxydopamine parkinson's disease model. Mov Disord. 2017;32:1547-1556 pubmed publisher
SÃ©rriÃ¨re S, DomÃ©nÃ© A, Vercouillie J, Mothes C, Bodard S, Rodrigues N, et al. Assessment of the Protection of Dopaminergic Neurons by an Î±7 Nicotinic Receptor Agonist, PHA 543613 Using [(18)F]LBT-999 in a Parkinson's Disease Rat Model. Front Med (Lausanne). 2015;2:61 pubmed publisher
Ray A, Martinez B, Berkowitz L, Caldwell G, Caldwell K. Mitochondrial dysfunction, oxidative stress, and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson's model. Cell Death Dis. 2014;5:e984 pubmed publisher
Reinhardt P, Glatza M, Hemmer K, Tsytsyura Y, Thiel C, Höing S, et al. Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling. PLoS ONE. 2013;8:e59252 pubmed publisher
Fouillet A, Levet C, Virgone A, Robin M, Dourlen P, Rieusset J, et al. ER stress inhibits neuronal death by promoting autophagy. Autophagy. 2012;8:915-26 pubmed publisher
Kitta T, Chancellor M, de Groat W, Kuno S, Nonomura K, Yoshimura N. Suppression of bladder overactivity by adenosine A2A receptor antagonist in a rat model of Parkinson disease. J Urol. 2012;187:1890-7 pubmed publisher
Grau C, Greene L. Use of PC12 cells and rat superior cervical ganglion sympathetic neurons as models for neuroprotective assays relevant to Parkinson's disease. Methods Mol Biol. 2012;846:201-11 pubmed publisher
Malagelada C, Jin Z, Jackson Lewis V, Przedborski S, Greene L. Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease. J Neurosci. 2010;30:1166-75 pubmed publisher
Malagelada C, Jin Z, Greene L. RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation. J Neurosci. 2008;28:14363-71 pubmed publisher

product information

brand :

Tocris

master code :

2547

SKU :

2547/50

product name :

6-Hydroxydopamine hydrobromide

description :

Selective catecholaminergic neurotoxin

target :

Additional Dopaminergic-related Products

category :

Small Molecules

unit size :

50 mg

observed molecular weight :

250.09

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson s disease.

catalog number base :

2547

product keywords :

Selective catecholaminergic neurotoxin Dopamine Receptors adrenoceptors adrenergic dopaminergic neurotoxins parkinson s parkinsons 6-OHDA Dopaminergic-Related Adrenergic Related Compounds 2547,

extended description :

Selective catecholaminergic neurotoxin

chemical name text :

5-(2-Aminoethyl)-1,2,4-benzenetriol hydrobromide

formula :

C 8 H 11 NO 3 .HBr

formula text :

C8H11NO3.HBr

cas num :

636-00-0

2020 USD :

2021 USD :

86 USD

alt names :

6-OHDA

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage