product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
PKI 14-22 amide, myristoylated
catalog :
2546/1
quantity :
1 mg
price :
191 USD
more info or order :
citations: 18
Reference
Jakobsen E, Lange S, Bak L. Soluble adenylyl cyclase-mediated cAMP signaling and the putative role of PKA and EPAC in cerebral mitochondrial function. J Neurosci Res. 2019;97:1018-1038 pubmed publisher
Al Amily I, Dunér P, Groop L, Salehi A. The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent. Pflugers Arch. 2019;471:633-645 pubmed publisher
Hamnett R, Crosby P, Chesham J, Hastings M. Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling. Nat Commun. 2019;10:542 pubmed publisher
Stival C, Ritagliati C, Xu X, Gervasi M, Luque G, Baró Graf C, et al. Disruption of protein kinase A localization induces acrosomal exocytosis in capacitated mouse sperm. J Biol Chem. 2018;293:9435-9447 pubmed publisher
Hashimotodani Y, Nasrallah K, Jensen K, Chavez A, Carrera D, Castillo P. LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance. Neuron. 2017;95:928-943.e3 pubmed publisher
Jantarajit W, Lertsuwan K, Teerapornpuntakit J, Krishnamra N, Charoenphandhu N. CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels. Am J Physiol Cell Physiol. 2017;313:C118-C129 pubmed publisher
Singh J, Wen X, Scales S. The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels. J Biol Chem. 2015;290:29663-75 pubmed publisher
Muñoz Llancao P, Henríquez D, Wilson C, Bodaleo F, Boddeke E, Lezoualc h F, et al. Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B. J Neurosci. 2015;35:11315-29 pubmed publisher
Watson R, Buck J, Levin L, Winger R, Wang J, Arase H, et al. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. J Exp Med. 2015;212:1021-41 pubmed publisher
Adelfinger L, Turecek R, Ivankova K, Jensen A, Moss S, Gassmann M, et al. GABAB receptor phosphorylation regulates KCTD12-induced K? current desensitization. Biochem Pharmacol. 2014;91:369-79 pubmed publisher
Okumura T, Harada K, Oue K, Zhang J, Asano S, Hayashiuchi M, et al. Phospholipase C-related catalytically inactive protein (PRIP) regulates lipolysis in adipose tissue by modulating the phosphorylation of hormone-sensitive lipase. PLoS ONE. 2014;9:e100559 pubmed publisher
Wang C, Held R, Hall B. SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks. PLoS ONE. 2013;8:e83941 pubmed publisher
Caiati M, Safiulina V, Fattorini G, Sivakumaran S, Legname G, Cherubini E. PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus. J Neurosci. 2013;33:2973-83 pubmed publisher
Dalvi P, Nazarians Armavil A, Purser M, Belsham D. Glucagon-like peptide-1 receptor agonist, exendin-4, regulates feeding-associated neuropeptides in hypothalamic neurons in vivo and in vitro. Endocrinology. 2012;153:2208-22 pubmed publisher
Maddugoda M, Stefani C, González Rodríguez D, Saarikangas J, Torrino S, Janel S, et al. cAMP signaling by anthrax edema toxin induces transendothelial cell tunnels, which are resealed by MIM via Arp2/3-driven actin polymerization. Cell Host Microbe. 2011;10:464-74 pubmed publisher
Meitzen J, Luoma J, Stern C, Mermelstein P. ?1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem. 2011;116:984-95 pubmed publisher
Tseng W, Graham L, Geng Y, Reddy A, Lu J, Effros R, et al. PKA-induced receptor activator of NF-kappaB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification. J Biol Chem. 2010;285:29925-31 pubmed publisher
Liu J, Lu W, Reigada D, Nguyen J, Laties A, Mitchell C. Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery. Invest Ophthalmol Vis Sci. 2008;49:772-80 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2546
SKU :
2546/1
product name :
PKI 14-22 amide, myristoylated
description :
Cell-permeable protein kinase A inhibitor
target :
Protein Kinase A Inhibitors
unit size :
1 mg
category :
Peptides
purity :
95%
storage :
Store at -20°C
observed molecular weight :
1209.5
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=peptides
details of functionality :
PKI 14-22 amide, myristoylated is a cell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (Ki = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1).
product keywords :
Cell-permeable protein kinases A inhibitors inhibits Cell permeable PKA PKI14-22 amide myristoylated Protein kinase inhibitor-(14-22)-amide, myristoylated Protein Kinase A 2546,
extended description :
Cell-permeable protein kinase A inhibitor
formula :
C53H100N20O12
formula text :
C53H100N20O12
cas num :
201422-03-9
USD :
183
USD 2025 :
191 USD
product details :
Cell-permeable protein kinase A inhibitor
alt names :
Protein kinase inhibitor-(14-22)-amide,myristoylated
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK