Ki 8751 | Tocris Bioscience 2542 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ki 8751

catalog :

2542

quantity :

10 mg (also 50 mg)

price :

231 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Page D, Thuret R, Venkatraman L, Takahashi T, Bentley K, Herbert S. Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis. Cell Rep. 2019;27:3139-3151.e5 pubmed publisher
Marino S, Bishop R, Capulli M, Sophocleous A, Logan J, Mollat P, et al. Regulation of breast cancer induced bone disease by cancer-specific IKKβ. Oncotarget. 2018;9:16134-16148 pubmed publisher
Kawakami J, Martinez Y, Sasaki B, Harris M, Kurata W, Lau A. Investigation of a novel molecular descriptor for the lead optimization of 4-aminoquinazolines as vascular endothelial growth factor receptor-2 inhibitors: application for quantitative structure-activity relationship analysis in lead optimization. Bioorg Med Chem Lett. 2011;21:1371-5 pubmed publisher

product information

brand :

Tocris

master code :

2542

SKU :

2542/10

product name :

Ki 8751

description :

Potent, selective VEGFR-2 inhibitor

target :

VEGF Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

97%

observed molecular weight :

469.41

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC50 = 0.9 nM). Displays some inhibitory activity towards c-Kit, PDGFR and FGFR-2 (IC50 values range from 40 to 170 nM) but is highly selective over other receptor tyrosine kinases (IC50 10000 nM for FGFR-2, EGFR and HGFR). Inhibits VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC) and inhibits tumor growth in vivo ; antiangiogenic.

catalog number base :

2542

product keywords :

Potent selective VEGFR-2 inhibitors inhibits Vascular Endothelial Growth Factors Receptors KDR Flt Receptor Tyrosine Kinases RTKs Ki8751 VEGFR 2542, VEGFR, VEGF R

extended description :

Potent, selective VEGFR-2 inhibitor

chemical name text :

N-(2,4-Difluorophenyl)-N -[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea

formula :

C 24 H 18 F 3 N 3 O 4

formula text :

C24H18F3N3O4

cas num :

228559-41-9

2020 USD :

222

2021 USD :

231 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage