IKK 16 | Tocris Bioscience 2539 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

IKK 16

catalog :

2539

quantity :

10 mg (also 50 mg)

price :

259 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Jones D, Jenney A, Swantek J, Burke J, Lauffenburger D, Sorger P. Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation. Nat Chem Biol. 2017;13:38-45 pubmed publisher
Rycaj K, Cho E, Liu X, Chao H, Liu B, Li Q, et al. Longitudinal tracking of subpopulation dynamics and molecular changes during LNCaP cell castration and identification of inhibitors that could target the PSA-/lo castration-resistant cells. Oncotarget. 2016;7:14220-40 pubmed publisher
Cataldi M, Shah N, Felt S, Grdzelishvili V. Breaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1. Virology. 2015;485:340-54 pubmed publisher
Sordi R, Chiazza F, Johnson F, Patel N, Brohi K, Collino M, et al. Inhibition of I?B Kinase Attenuates the Organ Injury and Dysfunction Associated with Hemorrhagic Shock. Mol Med. 2015;21:563-75 pubmed publisher
Thein S, Pham A, Bayer K, Tao Cheng J, Dosemeci A. IKK regulates the deubiquitinase CYLD at the postsynaptic density. Biochem Biophys Res Commun. 2014;450:550-4 pubmed publisher
Ansbro M, Shukla S, Ambudkar S, Yuspa S, Li L. Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference. PLoS ONE. 2013;8:e60334 pubmed publisher
Brosnahan A, Vulchanova L, Witta S, Dai Y, Jones B, Brown D. Norepinephrine potentiates proinflammatory responses of human vaginal epithelial cells. J Neuroimmunol. 2013;259:8-16 pubmed publisher

product information

brand :

Tocris

master code :

2539

SKU :

2539/10

product name :

IKK 16

description :

Selective inhibitor of IKK

target :

IkB Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

520.09

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective inhibitor of I B kinase (IKK) (IC50 values are 40, 70 and 200 nM for IKK , IKK complex and IKK respectively). Inhibits TNF- -stimulated I B degradation and expression of adhesion molecules E-selectin, ICAM and VCAM (IC50 values are 1.0, 0.5, 0.3 and 0.3 u M respectively). Inhibits LPS-induced TNF- release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.

catalog number base :

2539

product keywords :

Selective inhibitors inhibits IKK I B IkappaB Kinases NF- B NF-kappaB NF-kB Transcription Factors Nuclear Factor Kappa B Cytokine Signaling Signalling IKK16 IkB Kinase NF-kB/IkB 2539,

extended description :

Selective inhibitor of IKK

chemical name text :

N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride

formula :

C 28 H 29 N 5 OS.HCl

formula text :

C28H29N5OS.HCl

cas num :

1186195-62-9

2020 USD :

249

2021 USD :

259 USD

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage