DPO-1 | Tocris Bioscience 2533 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

DPO-1

catalog :

2533

quantity :

10 mg (also 50 mg)

price :

173 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Ryland K, Hawkins A, Weisenberger D, Punj V, Borinstein S, Laird P, et al. Promoter Methylation Analysis Reveals That KCNA5 Ion Channel Silencing Supports Ewing Sarcoma Cell Proliferation. Mol Cancer Res. 2016;14:26-34 pubmed publisher
Ryland K, Svoboda L, Vesely E, McIntyre J, Zhang L, Martens J, et al. Polycomb-dependent repression of the potassium channel-encoding gene KCNA5 promotes cancer cell survival under conditions of stress. Oncogene. 2015;34:4591-600 pubmed publisher
Tabarean I. Electrical remodeling of preoptic GABAergic neurons involves the Kv1.5 subunit. PLoS ONE. 2014;9:e96643 pubmed publisher
Zhao N, Dong Q, Du L, Fu X, Du Y, Liao Y. Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells. PLoS ONE. 2013;8:e64629 pubmed publisher
Haim T, Wang W, Flagg T, Tones M, Bahinski A, Numann R, et al. Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents. J Mol Cell Cardiol. 2010;48:395-405 pubmed publisher

product information

brand :

Tocris

master code :

2533

SKU :

2533/10

product name :

DPO-1

description :

Blocker of KV1.5 channel and IKur current

target :

Voltage-gated Potassium Channel Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

340.44

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels (IC50 = 0.31 u M for rKV1.5). Displays selectivity for inhibition of IKur over Ito (8-fold), IK1, IKr and IKs (20-fold) in native myocytes and selectivity for rat recombinant KV1.5 over KV3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.

catalog number base :

2533

product keywords :

blockers KV15 channel IKur current Potassium KV Channels voltage-gated voltage-dependent K+ Diphenylphosphine oxide1 Diphenyl phosphine oxide-1 Voltage-Gated Potassium Channels 2533,

extended description :

Blocker of KV1.5 channel and IKur current

chemical name text :

[1S-(1 ,2 ,5 )]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphine oxide

formula :

C 22 H 29 OP

formula text :

C22H29OP

cas num :

43077-30-1

2020 USD :

166

2021 USD :

173 USD

alt names :

Diphenyl phosphine oxide-1

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage