TFB-TBOA | Tocris Bioscience 2532 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TFB-TBOA

catalog :

2532

quantity :

1 mg (also 10 mg)

price :

150 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
Zhang R, DU W, Prober D, Du J. Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors. Cell Rep. 2019;27:2871-2880.e2 pubmed publisher
Belozor O, Yakovleva D, Potapenko I, Shuvaev A, Smolnikova M, Vasilev A, et al. Extracellular S100β Disrupts Bergman Glia Morphology and Synaptic Transmission in Cerebellar Purkinje Cells. Brain Sci. 2019;9: pubmed publisher
Rocchio F, Tapella L, Manfredi M, Chisari M, Ronco F, Ruffinatti F, et al. Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer's disease mouse model. Cell Death Dis. 2019;10:24 pubmed publisher
Chai H, Diaz Castro B, Shigetomi E, Monte E, Octeau J, Yu X, et al. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron. 2017;95:531-549.e9 pubmed publisher
Canul Tec J, Assal R, Cirri E, Legrand P, Brier S, Chamot Rooke J, et al. Structure and allosteric inhibition of excitatory amino acid transporter 1. Nature. 2017;544:446-451 pubmed publisher
O Donnell J, Jackson J, Robinson M. Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes. J Neurosci. 2016;36:7109-27 pubmed publisher
Obba S, Hizir Z, Boyer L, Selimoglu Buet D, Pfeifer A, Michel G, et al. The PRKAA1/AMPKÎ±1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML. Autophagy. 2015;11:1114-29 pubmed publisher
Fleischer W, Theiss S, Slotta J, Holland C, Schnitzler A. High-frequency voltage oscillations in cultured astrocytes. Physiol Rep. 2015;3: pubmed publisher
Yan X, Maixner D, Yadav R, Gao M, Li P, Bartlett M, et al. Paclitaxel induces acute pain via directly activating toll like receptor 4. Mol Pain. 2015;11:10 pubmed publisher
Ivanov A, Malkov A, Waseem T, Mukhtarov M, Buldakova S, Gubkina O, et al. Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices. J Cereb Blood Flow Metab. 2014;34:397-407 pubmed publisher
Afzalov R, Pryazhnikov E, Shih P, Kondratskaya E, Zobova S, Leino S, et al. Low micromolar Ba(2+) potentiates glutamate transporter current in hippocampal astrocytes. Front Cell Neurosci. 2013;7:135 pubmed publisher
Zou S, Fitting S, Hahn Y, Welch S, El Hage N, Hauser K, et al. Morphine potentiates neurodegenerative effects of HIV-1 Tat through actions at ?-opioid receptor-expressing glia. Brain. 2011;134:3616-31 pubmed publisher

product information

brand :

Tocris

master code :

2532

SKU :

2532/1

product name :

TFB-TBOA

description :

High affinity EAAT1 and EAAT2 blocker

target :

Glutamate (EAAT) Transporter Inhibitors

category :

Small Molecules

unit size :

1 mg (also 10 mg)

purity :

98%

observed molecular weight :

426.35

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective glial glutamate transporter EAAT1 and EAAT2 inhibitor (IC50 values are 17, 22 and 300 nM for EAAT2, EAAT1 and EAAT3 respectively). Has no effect on EAAT4 and EAAT5, or a wide range of neuronal receptors and transporters. Attenuates glutamate-stimulated intracellular Na+ elevation in astrocytes in vitro (IC50 = 43 nM). Induces severe convulsions in vivo.

catalog number base :

2532

product keywords :

High affinity EAAT1 EAAT2 blockers EAAT Excitatory Amino Acid Transporters GLAST GLT-1 Glutamate Monoamine Neurotransmitter Glutamate Transporters 2532,

extended description :

High affinity EAAT1 and EAAT2 blocker

chemical name text :

(3S)-3-[[3-[[4-(Trifluoromethyl)benzoyl]amino]phenyl]methoxy]-L-aspartic acid

formula :

C 19 H 17 F 3 N 2 O 6

formula text :

C19H17F3N2O6

cas num :

480439-73-4

2020 USD :

142

2021 USD :

150 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage