TFB-TBOA | Tocris Bioscience 2532/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TFB-TBOA

catalog :

2532/1

quantity :

1 mg (also 10 mg)

price :

195 USD

more info or order :

Tocris Bioscience product webpage

citations: 17

Reference
Hosseini S, Michaelsen Preusse K, Grigoryan G, Chhatbar C, Kalinke U, Korte M. Type I Interferon Receptor Signaling in Astrocytes Regulates Hippocampal Synaptic Plasticity and Cognitive Function of the Healthy CNS. Cell Rep. 2020;31:107666 pubmed publisher
Martinez D, Rogers R, Hasser E, Hermann G, Kline D. Loss of excitatory amino acid transporter restraint following chronic intermittent hypoxia contributes to synaptic alterations in nucleus tractus solitarii. J Neurophysiol. 2020;123:2122-2135 pubmed publisher
Zhang R, DU W, Prober D, Du J. Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors. Cell Rep. 2019;27:2871-2880.e2 pubmed publisher
Belozor O, Yakovleva D, Potapenko I, Shuvaev A, Smolnikova M, Vasilev A, et al. Extracellular S100β Disrupts Bergman Glia Morphology and Synaptic Transmission in Cerebellar Purkinje Cells. Brain Sci. 2019;9: pubmed publisher
Rocchio F, Tapella L, Manfredi M, Chisari M, Ronco F, Ruffinatti F, et al. Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer's disease mouse model. Cell Death Dis. 2019;10:24 pubmed publisher
Chai H, Diaz Castro B, Shigetomi E, Monte E, Octeau J, Yu X, et al. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron. 2017;95:531-549.e9 pubmed publisher
Canul Tec J, Assal R, Cirri E, Legrand P, Brier S, Chamot Rooke J, et al. Structure and allosteric inhibition of excitatory amino acid transporter 1. Nature. 2017;544:446-451 pubmed publisher
O Donnell J, Jackson J, Robinson M. Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes. J Neurosci. 2016;36:7109-27 pubmed publisher
Dvorzhak A, Vagner T, Kirmse K, Grantyn R. Functional Indicators of Glutamate Transport in Single Striatal Astrocytes and the Influence of Kir4.1 in Normal and Huntington Mice. J Neurosci. 2016;36:4959-75 pubmed publisher
Obba S, Hizir Z, Boyer L, Selimoglu Buet D, Pfeifer A, Michel G, et al. The PRKAA1/AMPKÎ±1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML. Autophagy. 2015;11:1114-29 pubmed publisher
Fleischer W, Theiss S, Slotta J, Holland C, Schnitzler A. High-frequency voltage oscillations in cultured astrocytes. Physiol Rep. 2015;3: pubmed publisher
Yan X, Maixner D, Yadav R, Gao M, Li P, Bartlett M, et al. Paclitaxel induces acute pain via directly activating toll like receptor 4. Mol Pain. 2015;11:10 pubmed publisher
Ivanov A, Malkov A, Waseem T, Mukhtarov M, Buldakova S, Gubkina O, et al. Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices. J Cereb Blood Flow Metab. 2014;34:397-407 pubmed publisher
Afzalov R, Pryazhnikov E, Shih P, Kondratskaya E, Zobova S, Leino S, et al. Low micromolar Ba(2+) potentiates glutamate transporter current in hippocampal astrocytes. Front Cell Neurosci. 2013;7:135 pubmed publisher
Chan T, Her L, Liaw H, Chen M, Tzeng S. Retinoic acid mediates the expression of glutamate transporter-1 in rat astrocytes through genomic RXR action and non-genomic protein kinase C signaling pathway. J Neurochem. 2012;121:537-50 pubmed publisher
Jiang E, Yan X, Weng H. Glial glutamate transporter and glutamine synthetase regulate GABAergic synaptic strength in the spinal dorsal horn. J Neurochem. 2012;121:526-36 pubmed publisher
Zou S, Fitting S, Hahn Y, Welch S, El Hage N, Hauser K, et al. Morphine potentiates neurodegenerative effects of HIV-1 Tat through actions at ?-opioid receptor-expressing glia. Brain. 2011;134:3616-31 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2532

SKU :

2532/1

product name :

TFB-TBOA

description :

Potent and selective EAAT1 and EAAT2 blocker

target :

Glutamate (EAAT) Transporter Inhibitors

unit size :

1 mg (also 10 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

426.35

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TFB-TBOA is a potent and selective glial glutamate transporter EAAT1 and EAAT2 inhibitor (IC50 values are 17, 22 and 300 nM for EAAT2, EAAT1 and EAAT3, respectively). Exhibits selectivity for EAAT1 and EAAT2 over EAAT4 and EAAT5, and a wide range of neuronal receptors and transporters. In HEK293 cells expressing human EAAT1, 2, and 3, TFB-TBOA exhibited selectivity for hEAAT1 and hEAAT2 over hEAAT3 (respective IC50 values are 3.6, 10, and 120 nM), while in tsA201 cells expressing rat EAAT4, [3H]-d-Asp uptake was inhibited with an IC50 of 40 nM. Attenuates glutamate-stimulated intracellular Na+ elevation in astrocytes in vitro (IC50 = 43 nM). Induces severe convulsions in vivo .

product keywords :

High affinity EAAT1 EAAT2 blockers EAAT Excitatory Amino Acid Transporters GLAST GLT-1 Glutamate Monoamine Neurotransmitter Glutamate Transporters 2532,

extended description :

Potent and selective EAAT1 and EAAT2 blocker

chemical name text :

(3S)-3-[[3-[[4-(Trifluoromethyl)benzoyl]amino]phenyl]methoxy]-L-aspartic acid

formula :

C19H17F3N2O6

formula text :

C19H17F3N2O6

cas num :

480439-73-4

USD :

187

USD 2025 :

195 USD

product details :

Potent and selective EAAT1 and EAAT2 blocker

more info or order :

Tocris Bioscience product webpage