product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
RS 504393
catalog :
2517
quantity :
10 mg
price :
229 USD
more info or order :
citations: 15
Reference
Tong Y, Zhou L, Yang L, Guo P, Cao Y, Qin F, et al. Concomitant type I IFN and M-CSF signaling reprograms monocyte differentiation and drives pro-tumoral arginase production. EBioMedicine. 2019;39:132-144 pubmed publisher
Linde N, Casanova Acebes M, Sosa M, Mortha A, Rahman A, Farias E, et al. Macrophages orchestrate breast cancer early dissemination and metastasis. Nat Commun. 2018;9:21 pubmed publisher
Kwiatkowski K, Piotrowska A, Rojewska E, Makuch W, Mika J. The RS504393 Influences the Level of Nociceptive Factors and Enhances Opioid Analgesic Potency in Neuropathic Rats. J Neuroimmune Pharmacol. 2017;12:402-419 pubmed publisher
Lu W, Tang Y, Zhang Z, Zhang X, Yao Y, Fu C, et al. Inhibiting the mobilization of Ly6C(high) monocytes after acute myocardial infarction enhances the efficiency of mesenchymal stromal cell transplantation and curbs myocardial remodeling. Am J Transl Res. 2015;7:587-97 pubmed
Ayoub M, Zhang Y, Kelly R, See H, Johnstone E, McCall E, et al. Functional interaction between angiotensin II receptor type 1 and chemokine (C-C motif) receptor 2 with implications for chronic kidney disease. PLoS ONE. 2015;10:e0119803 pubmed publisher
Mazumdar S, Arendt L, Phillips S, Sedic M, Kuperwasser C, Gill G. CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer. PLoS ONE. 2015;10:e0121281 pubmed publisher
Lourenço S, Teixeira V, Kalber T, José R, Floto R, Janes S. Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors. J Immunol. 2015;194:3463-74 pubmed publisher
Matsubara K, Matsushita Y, Sakai K, Kano F, Kondo M, Noda M, et al. Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity. J Neurosci. 2015;35:2452-64 pubmed publisher
Kim J, Kim W, Le H, Moon U, Tran V, Kim H, et al. IL-33-induced hematopoietic stem and progenitor cell mobilization depends upon CCR2. J Immunol. 2014;193:3792-802 pubmed publisher
Arendt L, McCready J, Keller P, Baker D, Naber S, Seewaldt V, et al. Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis. Cancer Res. 2013;73:6080-93 pubmed publisher
Arms L, Girard B, Malley S, Vizzard M. Expression and function of CCL2/CCR2 in rat micturition reflexes and somatic sensitivity with urinary bladder inflammation. Am J Physiol Renal Physiol. 2013;305:F111-22 pubmed publisher
Miller R, Tran P, Das R, Ghoreishi Haack N, Ren D, Miller R, et al. CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proc Natl Acad Sci U S A. 2012;109:20602-7 pubmed publisher
Zhang Z, Dong Y, Lu Y, Cao S, Zhao Z, Gao Y. Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain. J Neuroinflammation. 2012;9:136 pubmed publisher
Simonson M, Ismail Beigi F. Endothelin-1 increases collagen accumulation in renal mesangial cells by stimulating a chemokine and cytokine autocrine signaling loop. J Biol Chem. 2011;286:11003-8 pubmed publisher
Yang S, IglayReger H, Kadouh H, Bodary P. Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy. Diabetologia. 2009;52:972-81 pubmed publisher
product information
brand :
Tocris
master code :
2517
SKU :
2517/10
product name :
RS 504393
description :
Highly selective CCR2 chemokine receptor antagonist
target :
Chemokine Receptor Antagonists
category :
Small Molecules
unit size :
10 mg
purity :
99%
observed molecular weight :
417.5
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Extremely selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and 100 u M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.
catalog number base :
2517
product keywords :
selective CCR2 chemokine receptor antagonists CXCR Chemokine Receptors RS504393 Chemokine CC Receptors 2517,
extended description :
Highly selective CCR2 chemokine receptor antagonist
chemical name text :
6-Methyl-1 -[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4 -piperidin]-2(1H)-one
formula :
C 25 H 27 N 3 O 3
formula text :
C25H27N3O3
cas num :
300816-15-3
2020 USD :
220
2021 USD :
229 USD
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK