product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
RS 504393
catalog :
2517/10
quantity :
10 mg
price :
297 USD
more info or order :
citations: 24
Reference
Wang K, Gu Y, Liao Y, Bang S, Donnelly C, Chen O, et al. PD-1 blockade inhibits osteoclast formation and murine bone cancer pain. J Clin Invest. 2020;130:3603-3620 pubmed publisher
Tong Y, Zhou L, Yang L, Guo P, Cao Y, Qin F, et al. Concomitant type I IFN and M-CSF signaling reprograms monocyte differentiation and drives pro-tumoral arginase production. EBioMedicine. 2019;39:132-144 pubmed publisher
Linde N, Casanova Acebes M, Sosa M, Mortha A, Rahman A, Farias E, et al. Macrophages orchestrate breast cancer early dissemination and metastasis. Nat Commun. 2018;9:21 pubmed publisher
Pei X, Zheng D, She S, Ma J, Guo C, Mo X, et al. The PSMP-CCR2 interactions trigger monocyte/macrophage-dependent colitis. Sci Rep. 2017;7:5107 pubmed publisher
Hu Y, Kodithuwakku N, Zhou L, Li C, Han D, Fang W, et al. Levo-Corydalmine Alleviates Neuropathic Cancer Pain Induced by Tumor Compression via the CCL2/CCR2 Pathway. Molecules. 2017;22: pubmed publisher
Kwiatkowski K, Piotrowska A, Rojewska E, Makuch W, Mika J. The RS504393 Influences the Level of Nociceptive Factors and Enhances Opioid Analgesic Potency in Neuropathic Rats. J Neuroimmune Pharmacol. 2017;12:402-419 pubmed publisher
Ito T, Ishigami M, Matsushita Y, Hirata M, Matsubara K, Ishikawa T, et al. Secreted Ectodomain of SIGLEC-9 and MCP-1 Synergistically Improve Acute Liver Failure in Rats by Altering Macrophage Polarity. Sci Rep. 2017;7:44043 pubmed publisher
Matsumoto T, Takahashi N, Kojima T, Yoshioka Y, Ishikawa J, Furukawa K, et al. Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages. Arthritis Res Ther. 2016;18:133 pubmed publisher
Lu W, Tang Y, Zhang Z, Zhang X, Yao Y, Fu C, et al. Inhibiting the mobilization of Ly6C(high) monocytes after acute myocardial infarction enhances the efficiency of mesenchymal stromal cell transplantation and curbs myocardial remodeling. Am J Transl Res. 2015;7:587-97 pubmed
Ayoub M, Zhang Y, Kelly R, See H, Johnstone E, McCall E, et al. Functional interaction between angiotensin II receptor type 1 and chemokine (C-C motif) receptor 2 with implications for chronic kidney disease. PLoS ONE. 2015;10:e0119803 pubmed publisher
Mazumdar S, Arendt L, Phillips S, Sedic M, Kuperwasser C, Gill G. CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer. PLoS ONE. 2015;10:e0121281 pubmed publisher
Lourenço S, Teixeira V, Kalber T, José R, Floto R, Janes S. Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors. J Immunol. 2015;194:3463-74 pubmed publisher
Matsubara K, Matsushita Y, Sakai K, Kano F, Kondo M, Noda M, et al. Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity. J Neurosci. 2015;35:2452-64 pubmed publisher
Kim J, Kim W, Le H, Moon U, Tran V, Kim H, et al. IL-33-induced hematopoietic stem and progenitor cell mobilization depends upon CCR2. J Immunol. 2014;193:3792-802 pubmed publisher
Ino K, Masuya M, Tawara I, Miyata E, Oda K, Nakamori Y, et al. Monocytes infiltrate the pancreas via the MCP-1/CCR2 pathway and differentiate into stellate cells. PLoS ONE. 2014;9:e84889 pubmed publisher
Sato S, Sakurai T, Ogasawara J, Takahashi M, Izawa T, Imaizumi K, et al. A circadian clock gene, Rev-erb?, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression. J Immunol. 2014;192:407-17 pubmed publisher
Fan Q, Gu D, Liu H, Yang L, Zhang X, Yoder M, et al. Defective TGF-? signaling in bone marrow-derived cells prevents hedgehog-induced skin tumors. Cancer Res. 2014;74:471-483 pubmed publisher
Arendt L, McCready J, Keller P, Baker D, Naber S, Seewaldt V, et al. Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis. Cancer Res. 2013;73:6080-93 pubmed publisher
Arms L, Girard B, Malley S, Vizzard M. Expression and function of CCL2/CCR2 in rat micturition reflexes and somatic sensitivity with urinary bladder inflammation. Am J Physiol Renal Physiol. 2013;305:F111-22 pubmed publisher
Miller R, Tran P, Das R, Ghoreishi Haack N, Ren D, Miller R, et al. CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proc Natl Acad Sci U S A. 2012;109:20602-7 pubmed publisher
Ganachari M, Guio H, Zhao N, Flores Villanueva P. Host gene-encoded severe lung TB: from genes to the potential pathways. Genes Immun. 2012;13:605-20 pubmed publisher
Zhang Z, Dong Y, Lu Y, Cao S, Zhao Z, Gao Y. Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain. J Neuroinflammation. 2012;9:136 pubmed publisher
Simonson M, Ismail Beigi F. Endothelin-1 increases collagen accumulation in renal mesangial cells by stimulating a chemokine and cytokine autocrine signaling loop. J Biol Chem. 2011;286:11003-8 pubmed publisher
Yang S, IglayReger H, Kadouh H, Bodary P. Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy. Diabetologia. 2009;52:972-81 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2517
SKU :
2517/10
product name :
RS 504393
description :
Highly selective CCR2 chemokine receptor antagonist
target :
Chemokine Receptor Antagonists
unit size :
10 mg
category :
Small Molecules
purity :
99%
storage :
Store at +4°C
observed molecular weight :
417.5
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
RS 504393 is an extremely selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and 100 u M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.
product keywords :
selective CCR2 chemokine receptor antagonists CXCR Chemokine Receptors RS504393 Chemokine CC Receptors 2517,
extended description :
Highly selective CCR2 chemokine receptor antagonist
chemical name text :
6-Methyl-1 -[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4 -piperidin]-2(1H)-one
formula :
C25H27N3O3
formula text :
C25H27N3O3
cas num :
300816-15-3
USD :
285
USD 2025 :
297 USD
product details :
Highly selective CCR2 chemokine receptor antagonist
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK