L-161,982 | Tocris Bioscience 2514/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

L-161,982

catalog :

2514/10

quantity :

10 mg

price :

388 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Lee B, Kim H, Shin T, Kang I, Lee J, Kim J, et al. PGE2 maintains self-renewal of human adult stem cells via EP2-mediated autocrine signaling and its production is regulated by cell-to-cell contact. Sci Rep. 2016;6:26298 pubmed publisher
Guillem Llobat P, Dovizio M, Bruno A, Ricciotti E, Cufino V, Sacco A, et al. Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells. Oncotarget. 2016;7:32462-77 pubmed publisher
Chia E, Kagota S, Wijekoon E, McGuire J. Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice. BMC Pharmacol. 2011;11:10 pubmed publisher
Sun X, Wang X, Wang G, Xia Y, Liu S, Qu M, et al. Lubiprostone reverses the inhibitory action of morphine on mucosal secretion in human small intestine. Dig Dis Sci. 2011;56:330-8 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2514

SKU :

2514/10

product name :

L-161,982

description :

Selective EP4 receptor antagonist

target :

Prostanoid Receptor Antagonists

unit size :

10 mg

category :

Small Molecules

purity :

99%

storage :

Desiccate at +4°C

observed molecular weight :

654.72

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

L-161,982 is an EP4 receptor antagonist that is selective over all other members of the prostanoid receptor family (Ki values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 u M for human EP4, TP, EP3, DP, FP, IP, EP1 and EP2 receptors respectively). Suppresses PGE2-induced bone formation in rats and prevents the nociceptive response induced by Misoprostol (Cat. No. 2297) in formalin-injected mice.

product keywords :

Selective EP4 receptors antagonists Prostanoid prostaglandins prostacyclins eicosanoids L161982 Prostanoid Receptors 2514,

extended description :

Selective EP4 receptor antagonist

chemical name text :

N-[[4 -[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1 -biphenyl]-2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide

formula :

C32H29F3N4O4S2

formula text :

C32H29F3N4O4S2

cas num :

147776-06-5

USD :

376

USD 2025 :

388 USD

product details :

Selective EP4 receptor antagonist

more info or order :

Tocris Bioscience product webpage