J 104129 fumarate | Tocris Bioscience 2507/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

J 104129 fumarate

catalog :

2507/10

quantity :

10 mg

price :

272 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Bader S, Diener M. Novel aspects of cholinergic regulation of colonic ion transport. Pharmacol Res Perspect. 2015;3:e00139 pubmed publisher

image

image 1 :

Cat.No. 2507 - J 104129 fumarate C24H36N2O2.C4H4O4 CAS No. 257603-40-0

product information

brand :

Tocris

catalog number base :

2507

SKU :

2507/10

product name :

J 104129 fumarate

units size :

10 mg

description :

Potent and selective M3 antagonist

target :

mAChR M3 Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

500.63

url print :

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details of functionality :

J 104129 fumarate is a potent M3 muscarinic receptor antagonist that displays ~ 120-fold selectivity over M2 receptors (Ki values are 4.2, 19 and 490 nM for human M3, M1 and M2 receptors respectively). Exhibits 250-fold bronchial selectivity; inhibits ACh-induced bronchoconstriction but not ACh-induced bradycardia (KB values are 3.3 and 170 nM for rat trachea M3 and rat right atria M2 receptors respectively).

top caption :

Potent and selective M3 antagonist

extended description :

Potent and selective M3 antagonist

chemical name text :

( R)- -Cyclopentyl- -hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide fumarate

formula :

C24H36N2O2.C4H4O4

formula text :

C24H36N2O2.C4H4O4

cas num :

257603-40-0

USD :

272 USD

product details :

Potent and selective M3 antagonist

storage :

Store at +4Â°C

more info or order :

Tocris Bioscience product webpage