SSR 69071 | Tocris Bioscience 2506/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SSR 69071

catalog :

2506/10

quantity :

10 mg

price :

301 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Li Y, Xia W, Liu Y, Remmer H, Voorhees J, Fisher G. Solar ultraviolet irradiation induces decorin degradation in human skin likely via neutrophil elastase. PLoS ONE. 2013;8:e72563 pubmed publisher
Reardon C, Lechmann M, Brüstle A, Gareau M, Shuman N, Philpott D, et al. Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation. Immunity. 2011;35:223-35 pubmed publisher
Hoffmann D, Textoris C, Oehme F, Klaassen T, Goppelt A, Römer A, et al. Pivotal role for alpha1-antichymotrypsin in skin repair. J Biol Chem. 2011;286:28889-901 pubmed publisher

image

image 1 :

Cat.No. 2506 - SSR 69071 C27H32N4O7S CAS No. 344930-95-6

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

2506

SKU :

2506/10

product name :

SSR 69071

Description :

Potent, orally active human leukocyte elastase inhibitor

target :

Synthetic Elastase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

556.63

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SSR 69071 is a high affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50 = 3.9 nM). Displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and 100 nM for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID50 = 2.8 mg/kg) and reduces infarct size in an in vivo acute model of coronary ischemia-reperfusion injury. Orally active.

extended description :

Potent, orally active human leukocyte elastase inhibitor

chemical name text :

2-[[6-Methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-4-one

formula :

C 27 H 32 N 4 O 7 S

formula text :

C27H32N4O7S

cas num :

344930-95-6

USD :

301 USD

product details :

Potent, orally active human leukocyte elastase inhibitor

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage