Bay 36-7620 | Tocris Bioscience 2501 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Bay 36-7620

catalog :

2501

quantity :

10 mg

price :

252 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Sexton R, Hachem A, Assi A, Bukhsh M, Gorski D, Speyer C. Metabotropic glutamate receptor-1 regulates inflammation in triple negative breast cancer. Sci Rep. 2018;8:16008 pubmed publisher
Dolfi S, Medina D, Kareddula A, Paratala B, Rose A, Dhami J, et al. Riluzole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells. Oncotarget. 2017;8:44639-44653 pubmed publisher
Pallo S, DiMaio J, Cook A, Nilsson B, Johnson G. Mechanisms of tau and AÎ²-induced excitotoxicity. Brain Res. 2016;1634:119-131 pubmed publisher
Valiya Veettil M, Dutta D, Bottero V, Bandyopadhyay C, Gjyshi O, Sharma Walia N, et al. Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation. PLoS Pathog. 2014;10:e1004389 pubmed publisher
Wall B, Wangari Talbot J, Shin S, Schiff D, Sierra J, Yu L, et al. Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cells. Pigment Cell Melanoma Res. 2014;27:263-74 pubmed publisher
Speyer C, Smith J, Banda M, Devries J, Mekani T, Gorski D. Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer. Breast Cancer Res Treat. 2012;132:565-73 pubmed publisher
Tronson N, Guzman Y, Guedea A, Huh K, Gao C, Schwarz M, et al. Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear. Biol Psychiatry. 2010;68:1007-15 pubmed publisher
Foong J, Bornstein J. mGluR(1) Receptors Contribute to Non-Purinergic Slow Excitatory Transmission to Submucosal VIP Neurons of Guinea-Pig Ileum. Front Neurosci. 2009;3:46 pubmed publisher
Le M, Chan J, Rosenberg S, Nabatian A, Merrigan K, Cohen Solal K, et al. The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells. J Invest Dermatol. 2010;130:2240-9 pubmed publisher

product information

brand :

Tocris

master code :

2501

SKU :

2501/10

product name :

Bay 36-7620

description :

mGlu1 inverse agonist

target :

Group I mGluR Antagonists

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

278.35

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 u M) with inverse agonist activity. Impairs classical conditioning and associated synaptic plasticity in hippocampal neurons. Exhibits neuroprotective and anticonvulsive effects in vivo following systemic administration.

catalog number base :

2501

product keywords :

Bay367620 selective non-competitive mGlu1 mGluR1 antagonists receptors inverse agonists metabotropic glutamate Glutamate (Metabotropic) Group I Receptors 2501,

extended description :

mGlu1 inverse agonist

chemical name text :

(3aS,6aS)-Hexahydro-5-methylene-6a-(2-naphthalenylmethyl)-1H-cyclopenta[c]furan-1-one

formula :

C 19 H 18 O 2

formula text :

C19H18O2

cas num :

232605-26-4

2020 USD :

247

2021 USD :

252 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage