Glycyl-H-1152 dihydrochloride | Tocris Bioscience 2485 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Glycyl-H-1152 dihydrochloride

catalog :

2485

quantity :

1 mg

price :

276 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Sadaie M, Dillon C, Narita M, Young A, Cairney C, Godwin L, et al. Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition. Mol Biol Cell. 2015;26:2971-85 pubmed publisher
Lawrence M, Chang C, Davies J. Transport of organic anions and cations in murine embryonic kidney development and in serially-reaggregated engineered kidneys. Sci Rep. 2015;5:9092 pubmed publisher
Araki Y, Zeng M, Zhang M, Huganir R. Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP. Neuron. 2015;85:173-89 pubmed publisher
Siegel N, Rosner M, Unbekandt M, Fuchs C, Slabina N, Dolznig H, et al. Contribution of human amniotic fluid stem cells to renal tissue formation depends on mTOR. Hum Mol Genet. 2010;19:3320-31 pubmed publisher

product information

brand :

Tocris

master code :

2485

SKU :

2485/1

product name :

Glycyl-H-1152 dihydrochloride

description :

Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414)

target :

Rho-kinase Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

99%

observed molecular weight :

449.4

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride (Cat. No. 2414) that displays improved ROCKII selectivity. IC50 values are 0.0118, 2.35, 2.57, 3.26, 10 and 10 u M for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.

catalog number base :

2485

product keywords :

selective Rho-Associated Coiled-Coil Kinases ROCK p160ROCK ROK Rho-Kinases Rho-kinases 2485,

extended description :

Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414)

chemical name text :

(S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride

formula :

C 18 H 24 N 4 O 3 S.2HCl

formula text :

C18H24N4O3S.2HCl

cas num :

913844-45-8

2020 USD :

267

2021 USD :

276 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage