Costunolide | Tocris Bioscience 2483 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Costunolide

catalog :

2483

quantity :

1 mg (also 10 mg)

price :

83 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Liu Q, Beyraghdar Kashkooli A, Manzano D, Pateraki I, Richard L, Kolkman P, et al. Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity. Nat Commun. 2018;9:4657 pubmed publisher
Ahmad F, Patrick S, Sheikh T, Sharma V, Pathak P, Malgulwar P, et al. Telomerase reverse transcriptase (TERT) - enhancer of zeste homolog 2 (EZH2) network regulates lipid metabolism and DNA damage responses in glioblastoma. J Neurochem. 2017;143:671-683 pubmed publisher
Ahmad F, Dixit D, Sharma V, Kumar A, Joshi S, Sarkar C, et al. Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma. Cell Death Dis. 2016;7:e2213 pubmed publisher
Ramirez A, Saillard N, Yang T, Franssen M, Bouwmeester H, Jongsma M. Biosynthesis of sesquiterpene lactones in pyrethrum (Tanacetum cinerariifolium). PLoS ONE. 2013;8:e65030 pubmed publisher
Liu Q, Majdi M, Cankar K, Goedbloed M, Charnikhova T, Verstappen F, et al. Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana. PLoS ONE. 2011;6:e23255 pubmed publisher

product information

brand :

Tocris

master code :

2483

SKU :

2483/1

product name :

Costunolide

description :

Inhibitor of human telomerase activity

target :

Telomerase Inhibitors

category :

Small Molecules

unit size :

1 mg (also 10 mg)

purity :

97%

observed molecular weight :

232.32

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of human telomerase activity (IC50 = 65 u M in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1 and disrupts NF- B activation. Displays anti-inflammatory, antifungal and antiviral properties.

catalog number base :

2483

product keywords :

inhibitors inhibits human telomerase activity Polymerases Protein Synthesis RNA DNA Telomerase DNA, RNA and Protein Synthesis Non-selective Antivirals 2483,

extended description :

Inhibitor of human telomerase activity

chemical name text :

(3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one

formula :

C 15 H 20 O 2

formula text :

C15H20O2

cas num :

553-21-9

2020 USD :

2021 USD :

83 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage