JTC 801 | Tocris Bioscience 2481 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

JTC 801

catalog :

2481

quantity :

10 mg (also 50 mg)

price :

158 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Zhang Y, Simpson Durand C, Standifer K. Nociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorder. Br J Pharmacol. 2015;172:571-82 pubmed publisher
Delaney G, Dawe K, Hogan R, Hunjan T, Roper J, Hazell G, et al. Role of nociceptin/orphanin FQ and NOP receptors in the response to acute and repeated restraint stress in rats. J Neuroendocrinol. 2012;24:1527-41 pubmed publisher
Mahmoud S, Margas W, Trapella C, Calo G, Ruiz Velasco V. Modulation of silent and constitutively active nociceptin/orphanin FQ receptors by potent receptor antagonists and Na+ ions in rat sympathetic neurons. Mol Pharmacol. 2010;77:804-17 pubmed publisher

product information

brand :

Tocris

master code :

2481

SKU :

2481/10

product name :

JTC 801

description :

Selective NOP antagonist

target :

NOP Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

447.96

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

High affinity, selective NOP receptor antagonist (Ki = 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human u -, - and -opioid receptors respectively. Exhibits anti-nociceptive effects in acute pain models in vivo . Orally active.

catalog number base :

2481

product keywords :

Selective NOP antagonists Nociceptin Receptors ORL1 OP4 Opioids JTC801 NOP Receptors 2481,

extended description :

Selective NOP antagonist

chemical name text :

N-(4-Amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]benzamide hydrochloride

formula :

C 26 H 25 N 3 O 2 .HCl

formula text :

C26H25N3O2.HCl

cas num :

244218-51-7

2020 USD :

154

2021 USD :

158 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage