product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
JTE 907
catalog :
2479
quantity :
10 mg (also 50 mg)
price :
227 USD
more info or order :
citations: 9
Reference
Tan R, Cao L. Cannabinoid WIN-55,212-2 mesylate inhibits tumor necrosis factor-α-induced expression of nitric oxide synthase in dorsal root ganglion neurons. Int J Mol Med. 2018;42:919-925 pubmed publisher
Wang S, Chennupati R, Kaur H, Iring A, Wettschureck N, Offermanns S. Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. J Clin Invest. 2016;126:4527-4536 pubmed publisher
Kong Y, Wang W, Zhang C, Wu Y, Liu Y, Zhou X. Cannabinoid WIN?55,212?2 mesylate inhibits ADAMTS?4 activity in human osteoarthritic articular chondrocytes by inhibiting expression of syndecan?1. Mol Med Rep. 2016;13:4569-76 pubmed publisher
Zhou Y, Oudin M, Gajendra S, Sonego M, Falenta K, Williams G, et al. Regional effects of endocannabinoid, BDNF and FGF receptor signalling on neuroblast motility and guidance along the rostral migratory stream. Mol Cell Neurosci. 2015;64:32-43 pubmed publisher
Vicente Sánchez A, Sánchez Blázquez P, Rodríguez Muñoz M, Garzón J. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity. Mol Brain. 2013;6:42 pubmed publisher
Marini P, Cascio M, King A, Pertwee R, Ross R. Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors. Br J Pharmacol. 2013;169:887-99 pubmed publisher
Sánchez Blázquez P, Rodríguez Muñoz M, Vicente Sánchez A, Garzón J. Cannabinoid receptors couple to NMDA receptors to reduce the production of NO and the mobilization of zinc induced by glutamate. Antioxid Redox Signal. 2013;19:1766-82 pubmed publisher
Mair K, Robinson E, Kane K, Pyne S, Brett R, Pyne N, et al. Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery. Br J Pharmacol. 2010;161:176-92 pubmed publisher
Price D, Martinez A, Seillier A, Koek W, Acosta Y, Fernandez E, et al. WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Eur J Neurosci. 2009;29:2177-86 pubmed publisher
product information
brand :
Tocris
master code :
2479
SKU :
2479/10
product name :
JTE 907
description :
Selective CB2 receptor inverse agonist
target :
Cannabinoid R2 / CB2 Inverse Agonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
438.48
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Highly selective cannabinoid CB2 receptor inverse agonist. Binds with high affinity to rat, mouse and human CB2 receptors (Ki values are 0.38, 1.55 and 35.9 nM respectively). Produces anti-inflammatory effects in vivo .
catalog number base :
2479
product keywords :
Selective CB2 receptor antagonists inverse agonists cannabinoids Receptors JTE907 cb2r CB2 Receptors 2479,
extended description :
Selective CB2 receptor inverse agonist
chemical name text :
N-(1,3-Benzodioxol-5-ylmethyl)-1,2-dihydro-7-methoxy-2-oxo-8-(pentyloxy)-3-quinolinecarboxamide
formula :
C 24 H 26 N 2 O 6
formula text :
C24H26N2O6
cas num :
282089-49-0
2020 USD :
218
2021 USD :
227 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK