product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
SR 11302
catalog :
2476
quantity :
10 mg
price :
231 USD
more info or order :
citations: 25
Reference |
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Messerschmidt L, Fischer S, Wiedemann P, Bringmann A, Hollborn M. Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation. Mol Vis. 2019;25:329-344 pubmed
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Kleiner J, Hollborn M, Wiedemann P, Bringmann A. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells. Mol Vis. 2018;24:647-666 pubmed
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Han S, Ding S, Miao X, Lin Z, Lu G, Xiao W, et al. TGF-β1 expression in regulatory NK1.1-CD4+NKG2D+ T cells dependents on the PI3K-p85α/JNK, NF-κB and STAT3 pathways. Am J Cancer Res. 2018;8:489-501 pubmed
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Lee H, Park M, Son D, Song H, Kim J, Ko S, et al. Anti-cancer effect of snake venom toxin through down regulation of AP-1 mediated PRDX6 expression. Oncotarget. 2015;6:22139-51 pubmed
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Huang Z, Huang G, Li Q, Jin J. p38 mitogen-activated protein kinase/activator protein-1 involved in serum deprivation-induced human alkaline ceramidase 2 upregulation. Biomed Rep. 2015;3:225-229 pubmed
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van Vliet S, Vuist I, Lenos K, Tefsen B, Kalay H, Garcia Vallejo J, et al. Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL). J Biol Chem. 2013;288:27519-32 pubmed publisher
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product information
brand :
Tocris
master code :
2476
SKU :
2476/10
product name :
SR 11302
description :
AP-1 inhibitor; antitumor agent
target :
AP-1 Inhibitors
category :
Small Molecules
unit size :
10 mg
purity :
98%
observed molecular weight :
376.54
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo . Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC50 1 u M for RAR , RAR , RAR and RXR ).
catalog number base :
2476
product keywords :
inhibitors inhibits AP-1 transcription factors antitumor agent SR11302 AP-1 2476,
extended description :
AP-1 inhibitor; antitumor agent
chemical name text :
(E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
formula :
C 26 H 32 O 2
formula text :
C26H32O2
cas num :
160162-42-5
2020 USD :
226
2021 USD :
231 USD
storage :
Store at -20°C
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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