product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
SR 11302
catalog :
2476/10
quantity :
10 mg
price :
303 USD
more info or order :
citations: 32
Reference
Kuramoto H, Hirao K, Yumoto H, Hosokawa Y, Nakanishi T, Takegawa D, et al. Caffeic Acid Phenethyl Ester (CAPE) Induces VEGF Expression and Production in Rat Odontoblastic Cells. Biomed Res Int. 2019;2019:5390720 pubmed publisher
Chung J, Kim K, An S, Lee S, Lim B, Kang S, et al. Coxsackievirus and adenovirus receptor mediates the responses of endothelial cells to fluid shear stress. Exp Mol Med. 2019;51:144 pubmed publisher
Bawazeer M, Theoharides T. IL-33 stimulates human mast cell release of CCL5 and CCL2 via MAPK and NF-κB, inhibited by methoxyluteolin. Eur J Pharmacol. 2019;865:172760 pubmed publisher
Messerschmidt L, Fischer S, Wiedemann P, Bringmann A, Hollborn M. Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation. Mol Vis. 2019;25:329-344 pubmed
Martin Gallausiaux C, Larraufie P, Jarry A, Béguet Crespel F, Marinelli L, Ledue F, et al. Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells. Front Immunol. 2018;9:2838 pubmed publisher
Kim C, Hu B, Jadhav R, Jin J, Zhang H, Cavanagh M, et al. Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells. Cell Rep. 2018;25:2148-2162.e5 pubmed publisher
Kleiner J, Hollborn M, Wiedemann P, Bringmann A. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells. Mol Vis. 2018;24:647-666 pubmed
Tavares R, Pathak S. Induction of TNF, CXCL8 and IL-1β in macrophages by Helicobacter pylori secreted protein HP1173 occurs via MAP-kinases, NF-κB and AP-1 signaling pathways. Microb Pathog. 2018;125:295-305 pubmed publisher
Han S, Ding S, Miao X, Lin Z, Lu G, Xiao W, et al. TGF-β1 expression in regulatory NK1.1-CD4+NKG2D+ T cells dependents on the PI3K-p85α/JNK, NF-κB and STAT3 pathways. Am J Cancer Res. 2018;8:489-501 pubmed
Zhang W, Du L, Zheng X, Chen X, Shi C, Chen B, et al. Elevated sodium chloride drives type I interferon signaling in macrophages and increases antiviral resistance. J Biol Chem. 2018;293:1030-1039 pubmed publisher
Ali M, Dasari H, Van Keulen V, Cornec D, Vasmatzis G, Peikert T, et al. Microbial Antigens Stimulate Metalloprotease-7 Secretion in Human B-Lymphocytes Using mTOR-Dependent and Independent Pathways. Sci Rep. 2017;7:3869 pubmed publisher
Sun Y, Lin Z, Liu C, Gong Y, Liegl R, Fredrick T, et al. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med. 2017;214:1753-1767 pubmed publisher
Lee F, Hui C, Chang T, Chiou P. Alternative Splicing of Toll-Like Receptor 9 Transcript in Teleost Fish Grouper Is Regulated by NF-?B Signaling via Phosphorylation of the C-Terminal Domain of the RPB1 Subunit of RNA Polymerase II. PLoS ONE. 2016;11:e0163415 pubmed publisher
Bugel S, Wehmas L, La Du J, Tanguay R. Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium. Toxicol Appl Pharmacol. 2016;296:31-41 pubmed publisher
Zheng X, Cheng M, Xiang L, Liang J, Xie L, Zhang R. The AP-1 transcription factor homolog Pf-AP-1 activates transcription of multiple biomineral proteins and potentially participates in Pinctada fucata biomineralization. Sci Rep. 2015;5:14408 pubmed publisher
Nadeau Vallée M, Quiniou C, Palacios J, Hou X, Erfani A, Madaan A, et al. Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth. J Immunol. 2015;195:3402-15 pubmed publisher
Qi W, Li H, Cai X, Gu J, Meng J, Xie H, et al. Lipoxin A4 activates alveolar epithelial sodium channel gamma via the microRNA-21/PTEN/AKT pathway in lipopolysaccharide-induced inflammatory lung injury. Lab Invest. 2015;95:1258-68 pubmed publisher
Banskota S, Regmi S, Kim J. NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7. Mol Cancer. 2015;14:123 pubmed publisher
Chen Q, Chen P, Pang X, Hu Y, Zhang Y. Adrenomedullin Up-regulates the Expression of Vascular Endothelial Growth Factor in Epithelial Ovarian Carcinoma Cells via JNK/AP-1 Pathway. Int J Gynecol Cancer. 2015;25:953-60 pubmed publisher
Lee H, Park M, Son D, Song H, Kim J, Ko S, et al. Anti-cancer effect of snake venom toxin through down regulation of AP-1 mediated PRDX6 expression. Oncotarget. 2015;6:22139-51 pubmed
Oruqaj G, Karnati S, Vijayan V, Kotarkonda L, Boateng E, Zhang W, et al. Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling. Proc Natl Acad Sci U S A. 2015;112:E2048-57 pubmed publisher
Huang Z, Huang G, Li Q, Jin J. p38 mitogen-activated protein kinase/activator protein-1 involved in serum deprivation-induced human alkaline ceramidase 2 upregulation. Biomed Rep. 2015;3:225-229 pubmed
Pernet E, Guillemot L, Burgel P, Martin C, Lambeau G, Sermet Gaudelus I, et al. Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity. Nat Commun. 2014;5:5105 pubmed publisher
Mason C, Lee G, Dong Y, Zhou H, He L, Weiner C. Effect of prostaglandin E2 on multidrug resistance transporters in human placental cells. Drug Metab Dispos. 2014;42:2077-86 pubmed publisher
O Sullivan M, Hirota N, Martin J. Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor ?B in BEAS-2B cells. PLoS ONE. 2014;9:e95566 pubmed publisher
Kankaanranta H, Ilmarinen P, Zhang X, Adcock I, Lahti A, Barnes P, et al. Tumour necrosis factor-? regulates human eosinophil apoptosis via ligation of TNF-receptor 1 and balance between NF-?B and AP-1. PLoS ONE. 2014;9:e90298 pubmed publisher
Bakhru P, Sirisaengtaksin N, Soudani E, Mukherjee S, Khan A, Jagannath C. BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9. Cell Immunol. 2014;287:53-61 pubmed publisher
Kim S, Kaiser V, Beier E, Bechheim M, Guenthner Biller M, Ablasser A, et al. Self-priming determines high type I IFN production by plasmacytoid dendritic cells. Eur J Immunol. 2014;44:807-818 pubmed publisher
van Vliet S, Vuist I, Lenos K, Tefsen B, Kalay H, Garcia Vallejo J, et al. Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL). J Biol Chem. 2013;288:27519-32 pubmed publisher
Keasey M, Kang S, Lovins C, Hagg T. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Commun Signal. 2013;11:35 pubmed publisher
Sethi A, Mao W, Wordinger R, Clark A. Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2011;52:5240-50 pubmed publisher
Ivanova M, Luken K, Zimmer A, Lenzo F, Smith R, Arteel M, et al. Tamoxifen increases nuclear respiratory factor 1 transcription by activating estrogen receptor beta and AP-1 recruitment to adjacent promoter binding sites. FASEB J. 2011;25:1402-16 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2476
SKU :
2476/10
product name :
SR 11302
description :
AP-1 inhibitor; antitumor agent
target :
AP-1 Inhibitors
unit size :
10 mg
category :
Small Molecules
purity :
98%
storage :
Store at -20°C
observed molecular weight :
376.54
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
SR 11302 is an inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo . Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC50 1 u M for RAR , RAR , RAR and RXR ).
product keywords :
inhibitors inhibits AP-1 transcription factors antitumor agent SR11302 AP-1 2476,
extended description :
AP-1 inhibitor; antitumor agent
chemical name text :
(E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
formula :
C26H32O2
formula text :
C26H32O2
cas num :
160162-42-5
USD :
290
USD 2025 :
303 USD
product details :
AP-1 inhibitor; antitumor agent
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK