ZM 323881 hydrochloride | Tocris Bioscience 2475/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ZM 323881 hydrochloride

catalog :

2475/1

quantity :

1 mg (also 10 mg)

price :

157 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Page D, Thuret R, Venkatraman L, Takahashi T, Bentley K, Herbert S. Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis. Cell Rep. 2019;27:3139-3151.e5 pubmed publisher
Durré T, Morfoisse F, Erpicum C, Ebroin M, Blacher S, García Caballero M, et al. uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis. Nat Commun. 2018;9:5178 pubmed publisher
Busceti C, Di Menna L, Bianchi F, Mastroiacovo F, Di Pietro P, Traficante A, et al. Dickkopf-3 Causes Neuroprotection by Inducing Vascular Endothelial Growth Factor. Front Cell Neurosci. 2018;12:292 pubmed publisher
Hulse R, Drake R, Bates D, Donaldson L. The control of alternative splicing by SRSF1 in myelinated afferents contributes to the development of neuropathic pain. Neurobiol Dis. 2016;96:186-200 pubmed publisher
Maertens L, Erpicum C, Detry B, Blacher S, Lenoir B, Carnet O, et al. Bone marrow-derived mesenchymal stem cells drive lymphangiogenesis. PLoS ONE. 2014;9:e106976 pubmed publisher
Lakshmikanthan S, Sobczak M, Chun C, Henschel A, Dargatz J, Ramchandran R, et al. Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin ?v??. Blood. 2011;118:2015-26 pubmed publisher
Zhong H, Wang D, Wang N, RIOS Y, Huang H, Li S, et al. Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity. Cell Res. 2011;21:1080-7 pubmed publisher
Kawakami J, Martinez Y, Sasaki B, Harris M, Kurata W, Lau A. Investigation of a novel molecular descriptor for the lead optimization of 4-aminoquinazolines as vascular endothelial growth factor receptor-2 inhibitors: application for quantitative structure-activity relationship analysis in lead optimization. Bioorg Med Chem Lett. 2011;21:1371-5 pubmed publisher
Chandrasekharan U, Waitkus M, Kinney C, Walters Stewart A, DiCorleto P. Synergistic induction of mitogen-activated protein kinase phosphatase-1 by thrombin and epidermal growth factor requires vascular endothelial growth factor receptor-2. Arterioscler Thromb Vasc Biol. 2010;30:1983-9 pubmed publisher
Holmes K, Chapman E, See V, Cross M. VEGF stimulates RCAN1.4 expression in endothelial cells via a pathway requiring Ca2+/calcineurin and protein kinase C-delta. PLoS ONE. 2010;5:e11435 pubmed publisher
Huang Y, Yang C, Huang C, Tai M, Hsu K. Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor. J Neurosci. 2010;30:6080-93 pubmed publisher

image

image 1 :

Cat.No. 2475 - ZM 323881 hydrochloride C22H18FN3O2.HCl CAS No. 193000-39-4

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

2475

SKU :

2475/1

product name :

ZM 323881 hydrochloride

Description :

Potent, selective inhibitor of VEGFR-2

target :

VEGF Receptor Inhibitors

category :

Small Molecules

unit size :

1 mg (also 10 mg)

purity :

99%

observed molecular weight :

411.86

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ZM 323881 hydrochloride is a potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) activity. Selectively inhibits VEGFR-2 (IC50 = 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases such as PDGFR , FGFR1, EGFR and erbB2 (IC50 50 u M). Inhibits VEGF-A-induced endothelial cell proliferation in vitro (IC50 = 8 nM).

extended description :

Potent, selective inhibitor of VEGFR-2

chemical name text :

5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenol hydrochloride

formula :

C 22 H 18 FN 3 O 2 .HCl

formula text :

C22H18FN3O2.HCl

cas num :

193000-39-4

USD :

157 USD

product details :

Potent, selective inhibitor of VEGFR-2

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage