GW 3965 hydrochloride | Tocris Bioscience 2474 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GW 3965 hydrochloride

catalog :

2474

quantity :

1 mg (also 10 mg)

price :

131 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Dong B, Singh A, Guo G, Young M, Liu J. Activation of FXR by obeticholic acid induces hepatic gene expression of SR-BI through a novel mechanism of transcriptional synergy with the nuclear receptor LXR. Int J Mol Med. 2019;43:1927-1938 pubmed publisher
Gibson D, Collins F, Cousins F, Esnal Zufiaurre A, Saunders P. The impact of 27-hydroxycholesterol on endometrial cancer proliferation. Endocr Relat Cancer. 2018;25:381-391 pubmed publisher
Herold M, Breuer J, Hucke S, Knolle P, Schwab N, Wiendl H, et al. Liver X receptor activation promotes differentiation of regulatory T cells. PLoS ONE. 2017;12:e0184985 pubmed publisher
Kimura T, Nada S, Takegahara N, Okuno T, Nojima S, Kang S, et al. Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals. Nat Commun. 2016;7:13130 pubmed publisher
MenÃ©ndez GutiÃ©rrez M, RÅ‘szer T, Fuentes L, NÃºÃ±ez V, Escolano A, Redondo J, et al. Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling. J Clin Invest. 2015;125:809-23 pubmed publisher
Candelaria N, Addanki S, Zheng J, Nguyen Vu T, Karaboga H, Dey P, et al. Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells. PLoS ONE. 2014;9:e106289 pubmed publisher
Wahlang B, Falkner K, Clair H, Al Eryani L, Prough R, States J, et al. Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture. Toxicol Sci. 2014;140:283-97 pubmed publisher
Rondini E, Fang H, Runge Morris M, Kocarek T. Regulation of human cytosolic sulfotransferases 1C2 and 1C3 by nuclear signaling pathways in LS180 colorectal adenocarcinoma cells. Drug Metab Dispos. 2014;42:361-8 pubmed publisher
Gabbi C, Kong X, Suzuki H, Kim H, Gao M, Jia X, et al. Central diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptor ?. Proc Natl Acad Sci U S A. 2012;109:3030-4 pubmed publisher
Hatano Y, Man M, Uchida Y, Crumrine D, Mauro T, Feingold K, et al. Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators. J Allergy Clin Immunol. 2010;125:160-9.e1-5 pubmed publisher

product information

brand :

Tocris

master code :

2474

SKU :

2474/1

product name :

GW 3965 hydrochloride

description :

Orally active liver X receptor (LXR) agonist

target :

LXR-like Receptor Agonists

category :

Small Molecules

unit size :

1 mg (also 10 mg)

purity :

98%

observed molecular weight :

618.51

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective, orally active non-steroidal agonist for the liver X receptor (LXR). In cell-based reporter gene assays, acts as a full agonist of hLXR and hLXR (EC50 values are 190 and 30 nM respectively). Reduces angiotensin II-mediated increases in blood pressure; up-regulates ABCA1 gene expression and raises circulating HDL levels. Displays potent antiatherogenic activity in mouse models of atherosclerosis.

catalog number base :

2474

product keywords :

non-steroidal liver X receptor LXR agonists FXR Receptors Farnesoid LXR-like GW3965 hydrochloride GlaxoSmithKline GSK LXR-like Receptors 2474,

extended description :

Orally active liver X receptor (LXR) agonist

chemical name text :

3-[3-[[[2-Chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]benzeneacetic acid hydrochloride

formula :

C 33 H 31 NO 3 ClF 3 .HCl

formula text :

C33H31NO3ClF3.HCl

cas num :

405911-17-3

2020 USD :

124

2021 USD :

131 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage