TNP-ATP triethylammonium salt | Tocris Bioscience 2464/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TNP-ATP triethylammonium salt

catalog :

2464/5

quantity :

5 mg

price :

389 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
McEwan T, Sophocleous R, Cuthbertson P, Mansfield K, Sanderson Smith M, Sluyter R. Autocrine regulation of wound healing by ATP release and P2Y2 receptor activation. Life Sci. 2021;283:119850 pubmed publisher
Mohammed Z, Doran C, Grundy D, Nassar M. Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons. Sci Rep. 2017;7:45221 pubmed publisher
Haam J, Halmos K, Di S, Tasker J. Nutritional state-dependent ghrelin activation of vasopressin neurons via retrograde trans-neuronal-glial stimulation of excitatory GABA circuits. J Neurosci. 2014;34:6201-13 pubmed publisher
Shabir S, Cross W, Kirkwood L, Pearson J, Appleby P, Walker D, et al. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Am J Physiol Renal Physiol. 2013;305:F396-406 pubmed publisher
Manohar M, Hirsh M, Chen Y, Woehrle T, Karande A, Junger W. ATP release and autocrine signaling through P2X4 receptors regulate ?? T cell activation. J Leukoc Biol. 2012;92:787-94 pubmed publisher
Fritsche G, Nairz M, Libby S, Fang F, Weiss G. Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression. J Leukoc Biol. 2012;92:353-9 pubmed publisher

product information

brand :

Tocris

catalog number base :

2464

SKU :

2464/5

product name :

TNP-ATP triethylammonium salt

units size :

5 mg

description :

Potent and selective P2X antagonist

target :

P2X Receptor Antagonists

category :

Small Molecules

purity :

95%

observed molecular weight :

1123.04

url print :

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details of functionality :

TNP-ATP triethylammonium salt is a high affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X1, P2X3 and heteromeric P2X2/3 receptors with IC50 values of 6, 0.9 and 7 nM respectively. Displays 1000-fold selectivity over P2X2, P2X4 and P2X7.

top caption :

Potent and selective P2X antagonist

extended description :

Potent and selective P2X antagonist

chemical name text :

2 ,3 -O-(2,4,6-Trinitrophenyl)adenosine-5 -triphosphate tetra(triethylammonium) salt

formula :

C16H13N8O19P3.4C6H16N

formula text :

C16H13N8O19P3.4C6H16N

USD :

389 USD

product details :

Potent and selective P2X antagonist

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage