SCH 442416 | Tocris Bioscience 2463/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SCH 442416

catalog :

2463/1

quantity :

1 mg (also 10 mg, 50 mg)

price :

131 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
Núñez F, Taura J, Camacho J, López Cano M, Fernández Dueñas V, Castro N, et al. PBF509, an Adenosine A2A Receptor Antagonist With Efficacy in Rodent Models of Movement Disorders. Front Pharmacol. 2018;9:1200 pubmed publisher
Cheng R, Segala E, Robertson N, Deflorian F, DorÃ© A, Errey J, et al. Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity. Structure. 2017;25:1275-1285.e4 pubmed publisher
Ravani A, Vincenzi F, Bortoluzzi A, Padovan M, Pasquini S, Gessi S, et al. Role and Function of A2A and A? Adenosine Receptors in Patients with Ankylosing Spondylitis, Psoriatic Arthritis and Rheumatoid Arthritis. Int J Mol Sci. 2017;18: pubmed publisher
Fang F, Yu M, Cavanagh M, Hutter Saunders J, Qi Q, Ye Z, et al. Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals. Cell Rep. 2016;14:1218-1231 pubmed publisher
Sassi Y, Ahles A, Truong D, Baqi Y, Lee S, Husse B, et al. Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation. J Clin Invest. 2014;124:5385-97 pubmed publisher
Tosolini M, Pont F, BÃ©tous D, Ravet E, Ligat L, Lopez F, et al. Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A2a GÎ±s protein-coupled receptor tonic inhibition of mitochondrially induced cell death. Mol Cell Biol. 2015;35:479-95 pubmed publisher
Ross A, Venton B. Adenosine transiently modulates stimulated dopamine release in the caudate-putamen via A1 receptors. J Neurochem. 2015;132:51-60 pubmed publisher
Li H, Chuang A, O BRIEN J. Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina. Vis Neurosci. 2014;31:237-43 pubmed publisher
Vincenzi F, Corciulo C, Targa M, Merighi S, Gessi S, Casetta I, et al. Multiple sclerosis lymphocytes upregulate A2A adenosine receptors that are antiinflammatory when stimulated. Eur J Immunol. 2013;43:2206-16 pubmed publisher
Yu J, Huang X, Wu Q, Wang J, Yu X, Zhao P. Effect of A(2A) receptor antagonist (SCH 442416) on the mRNA expression of glutamate aspartate transporter and glutamine synthetase in rat retinal Müller cells under hypoxic conditions in vitro. Exp Ther Med. 2012;3:803-806 pubmed
Varani K, Padovan M, Vincenzi F, Targa M, Trotta F, Govoni M, et al. A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release. Arthritis Res Ther. 2011;13:R197 pubmed publisher
Pugliese A, Traini C, Cipriani S, Gianfriddo M, Mello T, Giovannini M, et al. The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices. Br J Pharmacol. 2009;157:818-30 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2463

SKU :

2463/1

product name :

SCH 442416

description :

Very selective, high affinity A2A antagonist

target :

Adenosine A2a Receptor Antagonists

unit size :

1 mg (also 10 mg, 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at RT

observed molecular weight :

389.42

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SCH 442416 is a selective adenosine A2A receptor antagonist; binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively). Displays 23000-fold selectivity for hA2A over hA1 in vitro with minimal affinity for hA2B and hA3 receptors (IC50 10 u M). Blocks the cytoprotective effect of A2A agonist CGS-21680 (Cat.No. 1063).

product keywords :

selective high affinity A2A antagonists Receptors adenosines SCH442416 adenosine 2a antagonist Adenosine A2A Receptors 2463,

extended description :

Very selective, high affinity A2A antagonist

chemical name text :

2-(2-Furanyl)-7-[3-(4-methoxyphenyl)propyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine

formula :

C20H19N7O2

formula text :

C20H19N7O2

cas num :

316173-57-6

USD :

129

USD 2025 :

131 USD

product details :

Very selective, high affinity A2A antagonist

more info or order :

Tocris Bioscience product webpage