Tropisetron hydrochloride | Tocris Bioscience 2459 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Tropisetron hydrochloride

catalog :

2459

quantity :

10 mg (also 50 mg)

price :

161 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Otvos R, Iyer J, van Elk R, Ulens C, Niessen W, Somsen G, et al. Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Toxins (Basel). 2015;7:2336-53 pubmed publisher
Johnson S, Krisp A, Bartman M. Hypoxia switches episodic breathing to singlet breathing in red-eared slider turtles (Trachemys scripta) via a tropisetron-sensitive mechanism. Respir Physiol Neurobiol. 2015;207:48-57 pubmed publisher
Sendin G, Bourien J, Rassendren F, Puel J, Nouvian R. Spatiotemporal pattern of action potential firing in developing inner hair cells of the mouse cochlea. Proc Natl Acad Sci U S A. 2014;111:1999-2004 pubmed publisher
Spilman P, Descamps O, Gorostiza O, Peters Libeu C, Poksay K, Matalis A, et al. The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model. Brain Res. 2014;1551:25-44 pubmed publisher

product information

brand :

Tocris

master code :

2459

SKU :

2459/10

product name :

Tropisetron hydrochloride

description :

Potent 5-HT3 antagonist; also 7 nAChR partial agonist

target :

5-HT3 Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

320.82

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, orally active 5-HT3 receptor antagonist. Antiemetic. Also partial agonist of 7 nAChR. Activates 7Q79G-GlyR chimeric ion channels (EC50 = 38 nM)

catalog number base :

2459

product keywords :

Potent 5-HT3 receptor antagonists orally active Serotonin Receptors ICS205930 Nicotinics nAChRs alpha7 a7 7 partial agonists chemogenetics Navoban ICS 205930 5-HT3 Receptors Nicotinic (a7) Receptors PSEMs 2459,

extended description :

Potent 5-HT3 antagonist; also 7 nAChR partial agonist

chemical name text :

(3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylic acid ester monohydrochloride

formula :

C 17 H 20 N 2 O 2 .HCl

formula text :

C17H20N2O2.HCl

cas num :

105826-92-4

2020 USD :

154

2021 USD :

161 USD

alt names :

Novaban, ICS 205930

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage