Co 101244 hydrochloride | Tocris Bioscience 2456 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Co 101244 hydrochloride

catalog :

2456

quantity :

10 mg (also 50 mg)

price :

195 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Quillinan N, Grewal H, Deng G, Shimizu K, Yonchek J, Strnad F, et al. Region-specific role for GluN2B-containing NMDA receptors in injury to Purkinje cells and CA1 neurons following global cerebral ischemia. Neuroscience. 2015;284:555-65 pubmed publisher
Mirante O, Brandalise F, Bohacek J, Mansuy I. Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala. Front Mol Neurosci. 2014;7:62 pubmed publisher
Peng H, Chang H, Lee S, Huang P, Chen G, Lai C, et al. TRPV1 mediates the uterine capsaicin-induced NMDA NR2B-dependent cross-organ reflex sensitization in anesthetized rats. Am J Physiol Renal Physiol. 2008;295:F1324-35 pubmed publisher

product information

brand :

Tocris

master code :

2456

SKU :

2456/10

product name :

Co 101244 hydrochloride

description :

GluN2B-selective NMDA antagonist

target :

NMDA Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

377.91

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Novel, potent and selective antagonist of GluN2B (formally NR2B)-containing NMDA receptors (IC50 values are 0.043, 100 and 100 u M for GluN1A/2B (NR1A/2B), GluN1A/2A (NR1A/2A) and GluN1A/2C (NR1A/2C) subunit combinations respectively). Displays neuroprotective effects in vivo and in vitro . . Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions .

catalog number base :

2456

product keywords :

selective NR2B antagonists Glutamate NMDA Receptors N-Methyl-D-Aspartate iGluR Ionotropic Co101244 hydrochloride PD174494 Ro63-1908 GluN2B PD 174494 Ro 63-1908 NMDA Receptors 2456,

extended description :

GluN2B-selective NMDA antagonist

chemical name text :

1-[2-(4-Hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]-4-piperidinol hydrochloride

formula :

C 21 H 27 NO 3 .HCl

formula text :

C21H27NO3.HCl

cas num :

193356-17-1

2020 USD :

187

2021 USD :

195 USD

alt names :

PD 174494, Ro 63-1908

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage