LY 379268 | Tocris Bioscience 2453 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LY 379268

catalog :

2453

quantity :

10 mg (also 50 mg)

price :

392 USD

more info or order :

Tocris Bioscience product webpage

citations: 19

Reference
Chandrasekaran K, Muragundla A, Demarest T, Choi J, Sagi A, Najimi N, et al. mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy. Ann Clin Transl Neurol. 2017;4:844-858 pubmed publisher
Scholler P, Nevoltris D, De Bundel D, Bossi S, Moreno Delgado D, Rovira X, et al. Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation. Nat Commun. 2017;8:1967 pubmed publisher
Johnson K, Mateo Y, Lovinger D. Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and dopamine release in the dorsal striatum. Neuropharmacology. 2017;117:114-123 pubmed publisher
Scholler P, Moreno Delgado D, Lecat Guillet N, Doumazane E, Monnier C, Charrier Savournin F, et al. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol. 2017;13:372-380 pubmed publisher
Erlandson M, Manzoni O, Bureau I. The Functional Organization of Neocortical Networks Investigated in Slices with Local Field Recordings and Laser Scanning Photostimulation. PLoS ONE. 2015;10:e0132008 pubmed publisher
Carbonaro T, Eshleman A, Forster M, Cheng K, Rice K, Gatch M. The role of 5-HT2A, 5-HT 2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice. Psychopharmacology (Berl). 2015;232:275-84 pubmed publisher
Wang M, Li Y, Snyder M, Wang H, Li F, Gao W. Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons. PLoS ONE. 2013;8:e61787 pubmed publisher
Trepanier C, Lei G, Xie Y, MacDonald J. Group II metabotropic glutamate receptors modify N-methyl-D-aspartate receptors via Src kinase. Sci Rep. 2013;3:926 pubmed publisher
Moreno J, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar Cuéllar F, et al. Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem. 2012;287:44301-19 pubmed publisher
Kurita M, Holloway T, García Bea A, Kozlenkov A, Friedman A, Moreno J, et al. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci. 2012;15:1245-54 pubmed publisher
Hinzman J, Thomas T, Quintero J, Gerhardt G, Lifshitz J. Disruptions in the regulation of extracellular glutamate by neurons and glia in the rat striatum two days after diffuse brain injury. J Neurotrauma. 2012;29:1197-208 pubmed publisher
Vinkers C, Hendriksen H, van Oorschot R, Cook J, Rallipalli S, Huang S, et al. Lifelong CRF overproduction is associated with altered gene expression and sensitivity of discrete GABA(A) and mGlu receptor subtypes. Psychopharmacology (Berl). 2012;219:897-908 pubmed publisher
Durand D, Carniglia L, Caruso C, Lasaga M. Reduced cAMP, Akt activation and p65-c-Rel dimerization: mechanisms involved in the protective effects of mGluR3 agonists in cultured astrocytes. PLoS ONE. 2011;6:e22235 pubmed publisher
Di Liberto V, Mudo G, Belluardo N. mGluR2/3 agonist LY379268, by enhancing the production of GDNF, induces a time-related phosphorylation of RET receptor and intracellular signaling Erk1/2 in mouse striatum. Neuropharmacology. 2011;61:638-45 pubmed publisher
Moreno J, Kurita M, Holloway T, Lopez J, Cadagan R, Martinez Sobrido L, et al. Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT?A and mGlu? receptors in the adult offspring. J Neurosci. 2011;31:1863-72 pubmed publisher
Chen H, Stoker A, Markou A. The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice. Psychopharmacology (Berl). 2010;209:343-50 pubmed publisher
Garcia B, Neely M, Deutch A. Cortical regulation of striatal medium spiny neuron dendritic remodeling in parkinsonism: modulation of glutamate release reverses dopamine depletion-induced dendritic spine loss. Cereb Cortex. 2010;20:2423-32 pubmed publisher
Bellesi M, Conti F. The mGluR2/3 agonist LY379268 blocks the effects of GLT-1 upregulation on prepulse inhibition of the startle reflex in adult rats. Neuropsychopharmacology. 2010;35:1253-60 pubmed publisher
Sekizawa S, Bechtold A, Tham R, Bonham A. A novel postsynaptic group II metabotropic glutamate receptor role in modulating baroreceptor signal transmission. J Neurosci. 2009;29:11807-16 pubmed publisher

product information

brand :

Tocris

master code :

2453

SKU :

2453/10

product name :

LY 379268

description :

Highly selective group II mGlu agonist

target :

Group II mGluR Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

187.15

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active. Caged LY 379268 is also available (Cat. No. 3332).

catalog number base :

2453

product keywords :

selective group II agonists Group Receptors mGlu2 mGluR2 mGlu3 mGluR3 Glutamate Metabotropic LY379268 Glutamate (Metabotropic) Group II Receptors 2453,

extended description :

Highly selective group II mGlu agonist

chemical name text :

(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid

formula :

C 7 H 9 NO 5

formula text :

C7H9NO5

cas num :

191471-52-0

2020 USD :

373

2021 USD :

392 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage