LY 344864 hydrochloride | Tocris Bioscience 2451 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LY 344864 hydrochloride

catalog :

2451

quantity :

10 mg (also 50 mg)

price :

214 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Scholpa N, Lynn M, Corum D, Boger H, Schnellmann R. 5-HT1F Receptor-Mediated Mitochondrial Biogenesis for the Treatment of Parkinson's Disease. Br J Pharmacol. 2017;: pubmed publisher
Garrett S, Whitaker R, Beeson C, Schnellmann R. Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury. J Pharmacol Exp Ther. 2014;350:257-64 pubmed publisher
Murray K, Stephens M, Rank M, D Amico J, Gorassini M, Bennett D. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol. 2011;106:925-43 pubmed publisher

product information

brand :

Tocris

master code :

2451

SKU :

2451/10

product name :

LY 344864 hydrochloride

description :

Potent and selective 5-HT1F agonist

target :

5-HT1F Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

387.88

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, selective 5-HT1F receptor agonist (EC50 = 3 nM). Displays 80-fold selectivity over other 5-HT receptors (Ki values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 u M for 5-HT1F, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT2A and 5-HT7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.

catalog number base :

2451

product keywords :

Potent selective 5-HT1F agonists Serotonin Receptors LY344864 hydrochloride 5-HT1F Receptors 2451,

extended description :

Potent and selective 5-HT1F agonist

chemical name text :

N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide hydrochloride

formula :

C 21 H 22 N 3 OF.HCl

formula text :

C21H22N3OF.HCl

cas num :

1217756-94-9

2020 USD :

207

2021 USD :

214 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage