product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
NF 157
catalog :
2450
quantity :
10 mg (also 50 mg)
price :
231 USD
more info or order :
citations: 12
Reference
Wu Y, Ge L, Li S, Song Z. Antagonism of P2Y11 receptor (P2Y11R) protects epidermal stem cells against UV-B irradiation. Am J Transl Res. 2019;11:4738-4745 pubmed
Dosch M, Zindel J, Jebbawi F, Melin N, Sánchez Taltavull D, Stroka D, et al. Connexin-43-dependent ATP release mediates macrophage activation during sepsis. elife. 2019;8: pubmed publisher
Kinoshita M, Hirayama Y, Fujishita K, Shibata K, Shinozaki Y, Shigetomi E, et al. Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes. EBioMedicine. 2018;32:72-83 pubmed publisher
Avanzato D, Genova T, Fiorio Pla A, Bernardini M, Bianco S, Bussolati B, et al. Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling. Sci Rep. 2016;6:32602 pubmed publisher
Nishimura Y, McLaughlin N, Pan J, Goldstein S, Hafenstein S, Shimizu H, et al. The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate. PLoS Pathog. 2015;11:e1005184 pubmed publisher
Ledderose C, Bao Y, Ledderose S, Woehrle T, Heinisch M, Yip L, et al. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis. 2016;213:456-64 pubmed publisher
Ren P, Zou G, Bailly B, Xu S, Zeng M, Chen X, et al. The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo. Emerg Microbes Infect. 2014;3:e62 pubmed publisher
Kawano A, Kadomatsu R, Ono M, Kojima S, Tsukimoto M, Sakamoto H. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors. PLoS ONE. 2015;10:e0127919 pubmed publisher
Braganhol E, Kukulski F, Lévesque S, Fausther M, Lavoie E, Zanotto Filho A, et al. Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells. Biochim Biophys Acta. 2015;1852:120-30 pubmed publisher
Manohar M, Hirsh M, Chen Y, Woehrle T, Karande A, Junger W. ATP release and autocrine signaling through P2X4 receptors regulate ?? T cell activation. J Leukoc Biol. 2012;92:787-94 pubmed publisher
Ohtomo K, Shatos M, Vrouvlianis J, Li D, Hodges R, Dartt D. Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells. Invest Ophthalmol Vis Sci. 2011;52:9503-15 pubmed publisher
Talasila A, Germack R, Dickenson J. Characterization of P2Y receptor subtypes functionally expressed on neonatal rat cardiac myofibroblasts. Br J Pharmacol. 2009;158:339-53 pubmed publisher
product information
brand :
Tocris
master code :
2450
SKU :
2450/10
product name :
NF 157
description :
Selective P2Y11 and P2X1 antagonist
target :
P2X Receptor Antagonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
observed molecular weight :
1437.08
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Purinergic receptor antagonist that potently inhibits P2Y11 receptor activity (IC50 = 463 nM). Displays selectivity for P2Y11 and P2X1 receptors over P2Y1, P2Y2, P2X2, P2X3, P2X4 and P2X7 receptors. Inhibits NAD+-induced activation of human granulocytes.
catalog number base :
2450
product keywords :
Selective P2Y11/P2X1 antagonists Receptors Purinergic purinoceptors NF157 P2X Receptors Purinergic P2Y Receptors 2450,
extended description :
Selective P2Y11 and P2X1 antagonist
chemical name text :
8,8 -[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
formula :
C 49 H 28 F 2 N 6 Na 6 O 23 S 6
formula text :
C49H28F2N6Na6O23S6
cas num :
104869-26-3
2020 USD :
222
2021 USD :
231 USD
storage :
Desiccate at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK