NF 157 | Tocris Bioscience 2450/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NF 157

catalog :

2450/10

quantity :

10 mg

price :

296 USD

more info or order :

Tocris Bioscience product webpage

citations: 13

Reference
Wu Y, Ge L, Li S, Song Z. Antagonism of P2Y11 receptor (P2Y11R) protects epidermal stem cells against UV-B irradiation. Am J Transl Res. 2019;11:4738-4745 pubmed
Dosch M, Zindel J, Jebbawi F, Melin N, Sánchez Taltavull D, Stroka D, et al. Connexin-43-dependent ATP release mediates macrophage activation during sepsis. elife. 2019;8: pubmed publisher
Kinoshita M, Hirayama Y, Fujishita K, Shibata K, Shinozaki Y, Shigetomi E, et al. Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes. EBioMedicine. 2018;32:72-83 pubmed publisher
Avanzato D, Genova T, Fiorio Pla A, Bernardini M, Bianco S, Bussolati B, et al. Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling. Sci Rep. 2016;6:32602 pubmed publisher
Nishimura Y, McLaughlin N, Pan J, Goldstein S, Hafenstein S, Shimizu H, et al. The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate. PLoS Pathog. 2015;11:e1005184 pubmed publisher
Ledderose C, Bao Y, Ledderose S, Woehrle T, Heinisch M, Yip L, et al. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis. 2016;213:456-64 pubmed publisher
Ren P, Zou G, Bailly B, Xu S, Zeng M, Chen X, et al. The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo. Emerg Microbes Infect. 2014;3:e62 pubmed publisher
Kawano A, Kadomatsu R, Ono M, Kojima S, Tsukimoto M, Sakamoto H. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors. PLoS ONE. 2015;10:e0127919 pubmed publisher
Braganhol E, Kukulski F, LÃ©vesque S, Fausther M, Lavoie E, Zanotto Filho A, et al. Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells. Biochim Biophys Acta. 2015;1852:120-30 pubmed publisher
Manohar M, Hirsh M, Chen Y, Woehrle T, Karande A, Junger W. ATP release and autocrine signaling through P2X4 receptors regulate ?? T cell activation. J Leukoc Biol. 2012;92:787-94 pubmed publisher
Fritsche G, Nairz M, Libby S, Fang F, Weiss G. Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression. J Leukoc Biol. 2012;92:353-9 pubmed publisher
Ohtomo K, Shatos M, Vrouvlianis J, Li D, Hodges R, Dartt D. Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells. Invest Ophthalmol Vis Sci. 2011;52:9503-15 pubmed publisher
Talasila A, Germack R, Dickenson J. Characterization of P2Y receptor subtypes functionally expressed on neonatal rat cardiac myofibroblasts. Br J Pharmacol. 2009;158:339-53 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2450

SKU :

2450/10

product name :

NF 157

description :

Selective P2Y11 and P2X1 antagonist

target :

P2X Receptor Antagonists

unit size :

10 mg

category :

Small Molecules

purity :

90%

storage :

Desiccate at RT

observed molecular weight :

1437.08

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NF 157 is a purinergic receptor antagonist that potently inhibits P2Y11 receptor activity (IC50 = 463 nM). Displays selectivity for P2Y11 and P2X1 receptors over P2Y1, P2Y2, P2X2, P2X3, P2X4 and P2X7 receptors. Inhibits NAD+-induced activation of human granulocytes. . This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content and the maximum solubility threshold to use in dilution calculations.

product keywords :

Selective P2Y11/P2X1 antagonists Receptors Purinergic purinoceptors NF157 antagonises inhibitors inhibits P2X Receptors Purinergic P2Y Receptors 2450,

extended description :

Selective P2Y11 and P2X1 antagonist

chemical name text :

8,8 -[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt

formula :

C49H28F2N6Na6O23S6

formula text :

C49H28F2N6Na6O23S6

cas num :

104869-26-3

USD :

287

USD 2025 :

296 USD

product details :

Selective P2Y11 and P2X1 antagonist

more info or order :

Tocris Bioscience product webpage