YM 298198 hydrochloride | Tocris Bioscience 2448 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

YM 298198 hydrochloride

catalog :

2448

quantity :

10 mg (also 50 mg)

price :

223 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Yasuda H, Kojima N, Hanamura K, Yamazaki H, Sakimura K, Shirao T. Drebrin Isoforms Critically Regulate NMDAR- and mGluR-Dependent LTD Induction. Front Cell Neurosci. 2018;12:330 pubmed publisher

product information

brand :

Tocris

master code :

2448

SKU :

2448/10

product name :

YM 298198 hydrochloride

description :

Highly potent, selective non-competitive mGlu1 antagonist

target :

Group I mGluR Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

378.92

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Non-competitive antagonist with high affinity and selectivity for mGlu1 receptors (Ki = 19 nM); inactive at other mGlu receptor subtypes (mGlu2-7), ionotropic receptors and glutamate transporters (IC50 10 u M). Inhibits glutamate-induced IP production more potently than CPCCOEt (IC50 values are 16 nM and 6.3 u M respectively), and is orally active in vivo , demonstrating an antinociceptive effect in hyperalgesic mice. . Desmethyl Derivative also available.

catalog number base :

2448

product keywords :

potent selective non-competitive mGlu1 mGluR1 antagonists Group I Receptors Glutamate Metabotropic YM298198 hydrochloride Glutamate (Metabotropic) Group I Receptors 2448,

extended description :

Highly potent, selective non-competitive mGlu1 antagonist

chemical name text :

6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride

formula :

C 18 H 22 N 4 OS.HCl

formula text :

C18H22N4OS.HCl

cas num :

1216398-09-2

2020 USD :

216

2021 USD :

223 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage