RITA | Tocris Bioscience 2443/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

RITA

catalog :

2443/1

quantity :

1 mg (also 10 mg)

price :

128 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Thotala D, Hallahan D, Yazlovitskaya E. Glycogen synthase kinase 3? inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway. Cell Death Differ. 2012;19:387-96 pubmed publisher

image

image 1 :

Cat.No. 2443 - RITA C14H12O3S2 CAS No. 213261-59-7

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

2443

SKU :

2443/1

product name :

RITA

Description :

MDM2-p53 interaction inhibitor

target :

p53 Activators

category :

Small Molecules

unit size :

1 mg (also 10 mg)

purity :

97%

observed molecular weight :

292.37

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

RITA is an anti-tumor agent that binds wild-type p53 (Kd = 1.5 nM) preventing p53-MDM2 (HDM2) interaction. Induces p53 accumulation and stimulates apoptosis in tumor cell lines expressing wild-type p53 in vitro and in vivo . Inhibits HPV-E6-mediated proteasomal degradation. Suppresses expression of cervical carcinoma HeLa xenografts in vivo .

extended description :

MDM2-p53 interaction inhibitor

chemical name text :

5,5 -(2,5-Furandiyl)bis-2-thiophenemethanol

formula :

C 14 H 12 O 3 S 2

formula text :

C14H12O3S2

cas num :

213261-59-7

USD :

128 USD

product details :

MDM2-p53 interaction inhibitor

alt names :

NSC 652287

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage