CGP 53353 | Tocris Bioscience 2442 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CGP 53353

catalog :

2442

quantity :

10 mg

price :

265 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Liu L, Gritz D, Parent C. PKC?II acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils. Mol Biol Cell. 2014;25:1446-57 pubmed publisher
He L, Wang T, Gao Q, Zhao G, Huang Y, Yu L, et al. Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells. J Biomed Sci. 2011;18:39 pubmed publisher
Ramana K, Tammali R, Reddy A, Bhatnagar A, Srivastava S. Aldose reductase-regulated tumor necrosis factor-alpha production is essential for high glucose-induced vascular smooth muscle cell growth. Endocrinology. 2007;148:4371-84 pubmed

product information

brand :

Tocris

master code :

2442

SKU :

2442/10

product name :

CGP 53353

description :

Selective inhibitor of PKC II

target :

Protein Kinase C Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

99%

observed molecular weight :

365.34

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective inhibitor of PKC II (IC50 values are 0.41 and 3.8 u M for PKC II and PKC I respectively). Also inhibits prionogenic Sup35 fibrillization (IC50 ~ 3.4 M) and inhibits de novo A 42 assembly in vitro .

catalog number base :

2442

product keywords :

Selective inhibitors inhibits PKCbetaII de novo A 4 42 beta42 assesmbly PKC PKM Protein Kinase C Kinases b-amyloid -Amyloid beta-Amyloid Precursor APP Secretase beta Peptides prionogenic Sup35 fibrillization CGP53353 amyloidbeta amyloidb Protein Kinase C Amyloid Beta Peptides 2442,

extended description :

Selective inhibitor of PKC II

chemical name text :

5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione

formula :

C 20 H 13 F 2 N 3 O 2

formula text :

C20H13F2N3O2

cas num :

145915-60-2

2020 USD :

257

2021 USD :

265 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage