CGP 53353 | Tocris Bioscience 2442/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CGP 53353

catalog :

2442/10

quantity :

10 mg

price :

329 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Liu L, Gritz D, Parent C. PKC?II acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils. Mol Biol Cell. 2014;25:1446-57 pubmed publisher
He L, Wang T, Gao Q, Zhao G, Huang Y, Yu L, et al. Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells. J Biomed Sci. 2011;18:39 pubmed publisher
Ramana K, Tammali R, Reddy A, Bhatnagar A, Srivastava S. Aldose reductase-regulated tumor necrosis factor-alpha production is essential for high glucose-induced vascular smooth muscle cell growth. Endocrinology. 2007;148:4371-84 pubmed

image

image 1 :

Cat.No. 2442 - CGP 53353 C20H13F2N3O2 CAS No. 145915-60-2

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

2442

SKU :

2442/10

product name :

CGP 53353

Description :

Selective inhibitor of PKC II

target :

Protein Kinase C Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

99%

observed molecular weight :

365.34

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CGP 53353 is a selective inhibitor of PKC II (IC50 values are 0.41 and 3.8 u M for PKC II and PKC I respectively). Also inhibits prionogenic Sup35 fibrillization (IC50 ~ 3.4 M) and inhibits de novo A 42 assembly in vitro .

extended description :

Selective inhibitor of PKC II

chemical name text :

5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione

formula :

C 20 H 13 F 2 N 3 O 2

formula text :

C20H13F2N3O2

cas num :

145915-60-2

USD :

329 USD

product details :

Selective inhibitor of PKC II

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage