GGTI 298 | Tocris Bioscience 2430 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GGTI 298

catalog :

2430

quantity :

1 mg

price :

212 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Domingue J, Ao M, Sarathy J, Rao M. Chenodeoxycholic acid requires activation of EGFR, EPAC, and Ca2+ to stimulate CFTR-dependent Cl- secretion in human colonic T84 cells. Am J Physiol Cell Physiol. 2016;311:C777-C792 pubmed publisher

product information

brand :

Tocris

master code :

2430

SKU :

2430/1

product name :

GGTI 298

description :

Geranylgeranyltransferase I (GGTase I) inhibitor

target :

Other Transferase Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

95%

observed molecular weight :

593.66

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor. Strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50 values are 3 and 10 u M respectively). Causes G0-G1 cell cycle block and apoptosis in A549 cells and inhibits cell invasion and migration in COLO 320CM cells.

catalog number base :

2430

product keywords :

GGTI298 geranylgeranyltransferase GGTase1 Protein Prenyltransferases Post-translational Modifications 2430,

extended description :

Geranylgeranyltransferase I (GGTase I) inhibitor

chemical name text :

N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucine methyl ester trifluoroacetate salt

formula :

C 27 H 33 N 3 O 3 S.CF 3 CO 2 H

formula text :

C27H33N3O3S.CF3CO2H

cas num :

1217457-86-7

2020 USD :

203

2021 USD :

212 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage