GGTI 298 | Tocris Bioscience 2430/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GGTI 298

catalog :

2430/1

quantity :

1 mg

price :

264 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Luttman J, Hoj J, Lin K, Lin J, Gu J, Rouse C, et al. ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells. Cell Rep. 2021;37:109880 pubmed publisher
Domingue J, Ao M, Sarathy J, Rao M. Chenodeoxycholic acid requires activation of EGFR, EPAC, and Ca2+ to stimulate CFTR-dependent Cl- secretion in human colonic T84 cells. Am J Physiol Cell Physiol. 2016;311:C777-C792 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

2430

SKU :

2430/1

product name :

GGTI 298

Description :

Geranylgeranyltransferase I (GGTase I) inhibitor

target :

Other Transferase Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

95%

observed molecular weight :

593.66

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GGTI 298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor. Strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50 values are 3 and 10 u M respectively). Causes G0-G1 cell cycle block and apoptosis in A549 cells and inhibits cell invasion and migration in COLO 320CM cells.

extended description :

Geranylgeranyltransferase I (GGTase I) inhibitor

chemical name text :

N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucine methyl ester trifluoroacetate salt

formula :

C 27 H 33 N 3 O 3 S.CF 3 CO 2 H

formula text :

C27H33N3O3S.CF3CO2H

cas num :

1217457-86-7

USD :

264 USD

product details :

Geranylgeranyltransferase I (GGTase I) inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage