chemical

BIBU 1361 dihydrochloride

2417

1 mg (also 10 mg)

79 USD

2417

2417/1

BIBU 1361 dihydrochloride

Selective inhibitor of EGFR-kinase

EGF Receptor Inhibitors

Small Molecules

1 mg (also 10 mg)

97%

516.87

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Potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). Displays ~ 100-fold lower potency against ErbB2 (IC50 = 290 nM) and is selective over a range of other related tyrosine kinases (IC50 10 u M). Blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Oral administration inhibits growth of established human xenografts in athymic mice.

2417

Selective inhibitors inhibits EGFR-kinases Epidermal Growth Factors Receptors ErbB Her Receptor Tyrosine Kinases RTKs BIBU1361 dihydrochloride EGFR 2417,

Selective inhibitor of EGFR-kinase

N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-pyrimido[5,4-d]pyrimidin-4-amine dihydrochloride

C 22 H 27 ClFN 7 .2HCl

C22H27ClFN7.2HCl

1643609-75-9

77

79 USD

Desiccate at +4°C