H 1152 dihydrochloride | Tocris Bioscience 2414 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

H 1152 dihydrochloride

catalog :

2414

quantity :

1 mg

price :

231 USD

more info or order :

Tocris Bioscience product webpage

citations: 15

Reference
Schipper K, Seinstra D, Paulien Drenth A, van der Burg E, Ramovs V, Sonnenberg A, et al. Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin. Nat Commun. 2019;10:3800 pubmed publisher
Garc a Morales V, Rodr guez Bey G, G mez P rez L, Dom nguez V as G, Gonz lez Forero D, Portillo F, et al. Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1. Nat Commun. 2019;10:3784 pubmed publisher
Messal H, Alt S, Ferreira R, Gribben C, Wang V, Cotoi C, et al. Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis. Nature. 2019;566:126-130 pubmed publisher
Pitha I, Oglesby E, Chow A, Kimball E, Pease M, Schaub J, et al. Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma. Transl Vis Sci Technol. 2018;7:6 pubmed publisher
Rath N, Munro J, Cutiongco M, Jagiełło A, Gadegaard N, McGarry L, et al. Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth. Cancer Res. 2018;78:3321-3336 pubmed publisher
Zenker J, White M, Gasnier M, Alvarez Y, Lim H, Bissiere S, et al. Expanding Actin Rings Zipper the Mouse Embryo for Blastocyst Formation. Cell. 2018;173:776-791.e17 pubmed publisher
Berenjeno I, Piñeiro R, Castillo S, Pearce W, McGranahan N, Dewhurst S, et al. Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling. Nat Commun. 2017;8:1773 pubmed publisher
Durkin C, Leite F, Cordeiro J, Handa Y, Arakawa Y, Valderrama F, et al. RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6. Dev Cell. 2017;41:315-329.e7 pubmed publisher
Sero J, Bakal C. Multiparametric Analysis of Cell Shape Demonstrates that β-PIX Directly Couples YAP Activation to Extracellular Matrix Adhesion. Cell Syst. 2017;4:84-96.e6 pubmed publisher
Rath N, Morton J, Julian L, Helbig L, Kadir S, McGhee E, et al. ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth. EMBO Mol Med. 2017;9:198-218 pubmed publisher
Aoun J, Hayashi M, Sheikh I, Sarkar P, Saha T, Ghosh P, et al. Anoctamin 6 Contributes to Cl- Secretion in Accessory Cholera Enterotoxin (Ace)-stimulated Diarrhea: AN ESSENTIAL ROLE FOR PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE (PIP2) SIGNALING IN CHOLERA. J Biol Chem. 2016;291:26816-26836 pubmed publisher
Sero J, Sailem H, Ardy R, Almuttaqi H, Zhang T, Bakal C. Cell shape and the microenvironment regulate nuclear translocation of NF-?B in breast epithelial and tumor cells. Mol Syst Biol. 2015;11:790 pubmed
Augspach A, List J, Wolf P, Bielek H, Schwan C, Elsässer Beile U, et al. Activation of RhoA,B,C by Yersinia Cytotoxic Necrotizing Factor (CNFy) induces apoptosis in LNCaP prostate cancer cells. Toxins (Basel). 2013;5:2241-57 pubmed publisher
Gilsbach B, Ho F, Vetter I, Van Haastert P, Wittinghofer A, Kortholt A. Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proc Natl Acad Sci U S A. 2012;109:10322-7 pubmed publisher
Kramar E, Chen L, Brandon N, Rex C, Liu F, Gall C, et al. Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. J Neurosci. 2009;29:12982-93 pubmed publisher

product information

brand :

Tocris

master code :

2414

SKU :

2414/1

product name :

H 1152 dihydrochloride

description :

Selective Rho-kinase (ROCK) inhibitor

target :

Rho-kinase Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

392.34

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Rho-kinase (ROCK) inhibitor that displays high selectivity over other protein kinases (IC50 values are 0.012, 0.180, 0.360, 0.745, 3.03, 5.68 and 28.3 u M for ROCKII, CAMKII, PKG, Aurora A, PKA, PKC and MLCK respectively). Inhibits sulprostone-induced contractions in guinea pig aorta (IC50 = 190 nM) and displays proerectile effects in rats. . Glycyl Derivative also available.

catalog number base :

2414

product keywords :

Selective Rho-kinase ROCK inhibitors inhibits Rho-Kinase Rho-Associated Coiled-Coil Kinases p160ROCK ROK H1152 dihydrochloride Rho-kinases 2414,

extended description :

Selective Rho-kinase (ROCK) inhibitor

chemical name text :

(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride

formula :

C 16 H 21 N 3 O 2 S.2HCl

formula text :

C16H21N3O2S.2HCl

cas num :

871543-07-6

2020 USD :

220

2021 USD :

231 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage