BIBO 3304 trifluoroacetate | Tocris Bioscience 2412/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BIBO 3304 trifluoroacetate

catalog :

2412/10

quantity :

10 mg (also 50 mg)

price :

437 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
Sánchez M, Els Heindl S, Beck Sickinger A, Wieneke R, Tampe R. Photoinduced receptor confinement drives ligand-independent GPCR signaling. Science. 2021;371: pubmed publisher
Maymon N, Mizrachi Zer Aviv T, Sabban E, Akirav I. Neuropeptide Y and cannabinoids interaction in the amygdala after exposure to shock and reminders model of PTSD. Neuropharmacology. 2020;162:107804 pubmed publisher
Choi B, Shin M, Kim E, Park J, Lee H, Kim S, et al. Elevated Neuropeptide Y in Endothelial Dysfunction Promotes Macrophage Infiltration and Smooth Muscle Foam Cell Formation. Front Immunol. 2019;10:1701 pubmed publisher
Alhadeff A, Su Z, Hernandez E, Klima M, Phillips S, Holland R, et al. A Neural Circuit for the Suppression of Pain by a Competing Need State. Cell. 2018;173:140-152.e15 pubmed publisher
Martins J, Elvas F, Brudzewsky D, Martins T, Kolomiets B, TralhÃ£o P, et al. Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro. ASN Neuro. 2015;7: pubmed publisher
Panaro B, Tough I, Engelstoft M, Matthews R, Digby G, MÃ¸ller C, et al. The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. Cell Metab. 2014;20:1018-29 pubmed publisher
Cohen S, Vainer E, Matar M, Kozlovsky N, Kaplan Z, Zohar J, et al. Diurnal fluctuations in HPA and neuropeptide Y-ergic systems underlie differences in vulnerability to traumatic stress responses at different zeitgeber times. Neuropsychopharmacology. 2015;40:774-90 pubmed publisher
Atasoy D, Betley J, Su H, Sternson S. Deconstruction of a neural circuit for hunger. Nature. 2012;488:172-7 pubmed publisher
Kojima S, Tohei A, Anzai N. A role for endogenous peptide YY in tachykinin NK(2) receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol. 2012;167:1362-8 pubmed publisher
Chen Z, Travers S, Travers J. Activation of NPY receptors suppresses excitatory synaptic transmission in a taste-feeding network in the lower brain stem. Am J Physiol Regul Integr Comp Physiol. 2012;302:R1401-10 pubmed publisher
Sousa D, Baldock P, Enriquez R, Zhang L, Sainsbury A, Lamghari M, et al. Neuropeptide Y Y1 receptor antagonism increases bone mass in mice. Bone. 2012;51:8-16 pubmed publisher
Pickens C, Adams Deutsch T, Nair S, Navarre B, Heilig M, Shaham Y. Effect of pharmacological manipulations of neuropeptide Y and corticotropin-releasing factor neurotransmission on incubation of conditioned fear. Neuroscience. 2009;164:1398-406 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2412

SKU :

2412/10

product name :

BIBO 3304 trifluoroacetate

description :

Highly selective NPY Y1 receptor antagonist

target :

NPY Receptor Antagonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

757.69

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BIBO 3304 trifluoroacetate is a high affinity NPY Y1 receptor antagonist (IC50 values are 0.38 and 0.72 nM at human and rat receptors respectively) that displays 2600-fold selectivity over Y2, Y4 and Y5 receptors. Inhibits NPY - and fasting-induced feeding in vivo following central administration. Also antagonizes anxiolytic-like effects of NPY.

product keywords :

selective NPY Y1 receptor antagonists Neuropeptide Y Receptors BIBO3304 trifluoroacetate neuropeptides NPY Receptors 2412,

extended description :

Highly selective NPY Y1 receptor antagonist

chemical name text :

N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]- -phenyl-benzeneacetamide ditrifluoroacetate

formula :

C29H35N7O3.2CF3CO2H

formula text :

C29H35N7O3.2CF3CO2H

cas num :

2310085-85-7

USD :

419

USD 2025 :

437 USD

product details :

Highly selective NPY Y1 receptor antagonist

more info or order :

Tocris Bioscience product webpage