L-371,257 | Tocris Bioscience 2410/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

L-371,257

catalog :

2410/10

quantity :

10 mg

price :

337 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Li X, Matsuura T, Xue M, Chen Q, Liu R, Lu J, et al. Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation. Cell Rep. 2021;36:109411 pubmed publisher
Lestanova Z, Puerta F, Alanazi M, Bacova Z, Kiss A, Castejon A, et al. Downregulation of Oxytocin Receptor Decreases the Length of Projections Stimulated by Retinoic Acid in the U-87MG Cells. Neurochem Res. 2017;42:1006-1014 pubmed publisher
Ho J, Anekonda V, Thompson B, Zhu M, Curry R, Hwang B, et al. Hindbrain oxytocin receptors contribute to the effects of circulating oxytocin on food intake in male rats. Endocrinology. 2014;155:2845-57 pubmed publisher
Ataka K, Nagaishi K, Asakawa A, Inui A, Fujimiya M. Alteration of antral and proximal colonic motility induced by chronic psychological stress involves central urocortin 3 and vasopressin in rats. Am J Physiol Gastrointest Liver Physiol. 2012;303:G519-28 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2410

SKU :

2410/10

product name :

L-371,257

description :

Potent and selective oxytocin receptor antagonist

target :

Oxytocin Receptor Antagonists

unit size :

10 mg

category :

Small Molecules

purity :

99%

storage :

Store at RT

observed molecular weight :

507.59

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

L-371,257 is a potent, high affinity human oxytocin (OT) receptor antagonist (Ki = 4.6 nM) that displays 800-fold selectivity over human arginine vasopressin receptors V1a and V2. Antagonizes oxytocin-induced contractions in isolated rat uterine tissue (pA2 = 8.44) and in anesthetised rats following intravenous and intraduodenal administration. Decreases length of U-87MG cell projections induced by retinoic acid (Cat.No.0695). Orally active.

product keywords :

Potent selective oxytocin receptors antagonists OT Receptors L371257 Oxytocin Receptors 2410,

extended description :

Potent and selective oxytocin receptor antagonist

chemical name text :

1-[4-[(1-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidine

formula :

C28H33N3O6

formula text :

C28H33N3O6

cas num :

162042-44-6

USD :

333

USD 2025 :

337 USD

product details :

Potent and selective oxytocin receptor antagonist

more info or order :

Tocris Bioscience product webpage