product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
MRS 2211
catalog :
2402/10
quantity :
10 mg (also 50 mg)
price :
157 USD
more info or order :
citations: 10
Reference
Madry C, Kyrargyri V, Arancibia Carcamo I, Jolivet R, Kohsaka S, Bryan R, et al. Microglial Ramification, Surveillance, and Interleukin-1? Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1. Neuron. 2018;97:299-312.e6 pubmed publisher
Kawano A, Kadomatsu R, Ono M, Kojima S, Tsukimoto M, Sakamoto H. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors. PLoS ONE. 2015;10:e0127919 pubmed publisher
Wang W, Luo J, Xiang F, Liu X, Jiang M, Liao L, et al. Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells. PLoS ONE. 2014;9:e110101 pubmed publisher
Giachini F, Leite R, Osmond D, Lima V, Inscho E, Webb R, et al. Anti-platelet therapy with clopidogrel prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive rats. PLoS ONE. 2014;9:e91890 pubmed publisher
Voss U, Turesson M, Robaye B, Boeynaems J, Olde B, Erlinge D, et al. The enteric nervous system of P2Y13 receptor null mice is resistant against high-fat-diet- and palmitic-acid-induced neuronal loss. Purinergic Signal. 2014;10:455-64 pubmed publisher
Pinheiro A, Paramos de Carvalho D, Certal M, Costa C, Magalhães Cardoso M, Ferreirinha F, et al. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal. 2013;11:70 pubmed publisher
Gao Z, Wei Q, Jayasekara M, Jacobson K. The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal. 2013;9:31-40 pubmed publisher
Balduini A, Di Buduo C, Malara A, Lecchi A, Rebuzzini P, Currao M, et al. Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes. Haematologica. 2012;97:1657-65 pubmed publisher
del Puerto A, Díaz Hernández J, Tapia M, Gomez Villafuertes R, Benitez M, Zhang J, et al. Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation. J Cell Sci. 2012;125:176-88 pubmed publisher
Ohtomo K, Shatos M, Vrouvlianis J, Li D, Hodges R, Dartt D. Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells. Invest Ophthalmol Vis Sci. 2011;52:9503-15 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2402
SKU :
2402/10
product name :
MRS 2211
description :
Competitive P2Y13 antagonist
target :
P2Y Receptor Antagonists
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
96%
storage :
Desiccate at -20°C
observed molecular weight :
474.66
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
MRS 2211 is a competitive P2Y13 receptor antagonist (pIC50 = 5.97) that displays 20-fold selectivity over P2Y1 and P2Y12 receptors.
product keywords :
Competitive P2Y13 antagonists Receptors Purinergic purinoceptors MRS2211 219554-11-7 antagonises inhibitors inhibits Purinergic P2Y Receptors 2402,
extended description :
Competitive P2Y13 antagonist
chemical name text :
2-[(2-Chloro-5-nitrophenyl)azo]-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde disodium salt
formula :
C14H10N4O8Na2PCl
formula text :
C14H10N4O8Na2PCl
USD :
155
USD 2025 :
157 USD
product details :
Competitive P2Y13 antagonist
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK