Eplerenone | Tocris Bioscience 2397/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Eplerenone

catalog :

2397/10

quantity :

10 mg (also 50 mg)

price :

206 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Ibrahim S, Xie W, Strong J, Tonello R, Berta T, Zhang J. Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and Dexamethasone Analgesia in an Animal Model of Low Back Pain. Front Cell Neurosci. 2018;12:453 pubmed publisher
Nguyen V, Farman N, Maubec E, Nassar D, Desposito D, Waeckel L, et al. Re-Epithelialization of Pathological Cutaneous Wounds Is Improved by Local Mineralocorticoid Receptor Antagonism. J Invest Dermatol. 2016;136:2080-2089 pubmed publisher
Maubec E, LaouÃ©nan C, Deschamps L, Nguyen V, Scheer Senyarich I, Wackenheim Jacobs A, et al. Topical Mineralocorticoid Receptor Blockade Limits Glucocorticoid-Induced Epidermal Atrophy in Human Skin. J Invest Dermatol. 2015;135:1781-1789 pubmed publisher
Williams T, Monticone S, Urbanet R, Bertello C, Giraudo G, Vettor R, et al. Genes implicated in insulin resistance are down-regulated in primary aldosteronism patients. Mol Cell Endocrinol. 2012;355:162-8 pubmed publisher
Urbanet R, Pilon C, Calcagno A, Peschechera A, Hubert E, Giacchetti G, et al. Analysis of insulin sensitivity in adipose tissue of patients with primary aldosteronism. J Clin Endocrinol Metab. 2010;95:4037-42 pubmed publisher

image

image 1 :

Cat.No. 2397 - Eplerenone C24H30O6 CAS No. 107724-20-9

product information

brand :

Tocris

catalog number base :

2397

SKU :

2397/10

product name :

Eplerenone

units size :

10 mg (also 50 mg)

description :

Selective mineralocorticoid receptor antagonist

target :

Mineralocorticoid Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

414.5

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Eplerenone is a selective mineralocorticoid (aldosterone) receptor antagonist (IC50 = 360 nM). Displays 27-fold selectivity over androgen, progesterone and estrogen receptors (IC50 10 u M). Orally active antihypertensive in vivo .

top caption :

Selective mineralocorticoid receptor antagonist

extended description :

Selective mineralocorticoid receptor antagonist

chemical name text :

(7 ,11 ,17 )-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid -lactone methyl ester

formula :

C24H30O6

formula text :

C24H30O6

cas num :

107724-20-9

USD :

206 USD

product details :

Selective mineralocorticoid receptor antagonist

alt names :

Inspra,Epoxymexrenone

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage