product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
JTE 013
catalog :
2392
quantity :
10 mg
price :
233 USD
more info or order :
citations: 20
Reference |
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Chumanevich A, Wedman P, Oskeritzian C. Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2. Mediators Inflamm. 2016;2016:1503206 pubmed publisher
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Miller A, Alvarez S, Spiegel S, Lebman D. Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells. Mol Cell Biol. 2008;28:4142-51 pubmed publisher
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product information
brand :
Tocris
master code :
2392
SKU :
2392/10
product name :
JTE 013
description :
S1P2 receptor antagonist
target :
Sphingosine-1-phosphate Receptor Antagonists
category :
Small Molecules
unit size :
10 mg
purity :
98%
observed molecular weight :
408.29
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Sphingosine-1-phosphate (S1P) receptor antagonist, highly selective for S1P2 (EDG-5). Inhibits S1P binding to human S1P2 receptors with an IC50 value of 17.6 nM. At concentrations up to 10 u M, displays 4.2% inhibition of S1P3 and does not antagonize S1P1. Enhances S1P-induced angiogenesis in vivo .
catalog number base :
2392
product keywords :
S1P2 receptor antagonists Receptors EDG5 Sphingosine-1-Phosphate JTE013 Sphingosine-1-phosphate Receptors 2392,
extended description :
S1P2 receptor antagonist
chemical name text :
1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide
formula :
C 17 H 19 N 7 OCl 2
formula text :
C17H19N7OCl2
cas num :
383150-41-2
2020 USD :
224
2021 USD :
233 USD
storage :
Store at +4°C
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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