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company name :
Tocris Bioscience
product type :
chemical
product name :
JTE 013
catalog :
2392
quantity :
10 mg
price :
233 USD
more info or order :
citations: 20
Reference
Matsushima Nishiwaki R, Yamada N, Fukuchi K, Kozawa O. Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2. PLoS ONE. 2018;13:e0209050 pubmed publisher
Wirrig C, McKean J, Wilson H, Nixon G. Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells. Biochem Pharmacol. 2016;115:43-50 pubmed publisher
Chumanevich A, Wedman P, Oskeritzian C. Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2. Mediators Inflamm. 2016;2016:1503206 pubmed publisher
Kellner Y, Fricke S, Kramer S, Iobbi C, Wierenga C, Schwab M, et al. Nogo-A controls structural plasticity at dendritic spines by rapidly modulating actin dynamics. Hippocampus. 2016;26:816-31 pubmed publisher
Durham J, Dulmovits B, Cronk S, Sheets A, Herman I. Pericyte chemomechanics and the angiogenic switch: insights into the pathogenesis of proliferative diabetic retinopathy?. Invest Ophthalmol Vis Sci. 2015;56:3441-59 pubmed publisher
Gu Y, SHEA J, Slattum G, Firpo M, Alexander M, Mulvihill S, et al. Defective apical extrusion signaling contributes to aggressive tumor hallmarks. elife. 2015;4:e04069 pubmed publisher
Fernández Pisonero I, López J, Onecha E, Dueñas A, Maeso P, Crespo M, et al. Synergy between sphingosine 1-phosphate and lipopolysaccharide signaling promotes an inflammatory, angiogenic and osteogenic response in human aortic valve interstitial cells. PLoS ONE. 2014;9:e109081 pubmed publisher
Shen Z, Liu C, Liu P, Zhao J, Xu W. Sphingosine 1-phosphate (S1P) promotes mitochondrial biogenesis in Hep G2 cells by activating Peroxisome proliferator-activated receptor ? coactivator 1? (PGC-1?). Cell Stress Chaperones. 2014;19:541-8 pubmed publisher
Beckham T, Cheng J, Lu P, Marrison S, Norris J, Liu X. Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. PLoS ONE. 2013;8:e76593 pubmed publisher
Beckham T, Cheng J, Lu P, Shao Y, Troyer D, Lance R, et al. Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling. Oncogenesis. 2013;2:e49 pubmed publisher
Stradner M, Gruber G, Angerer H, Huber V, Setznagl D, Kremser M, et al. Sphingosine 1-phosphate counteracts the effects of interleukin-1? in human chondrocytes. Arthritis Rheum. 2013;65:2113-22 pubmed publisher
Quint P, Ruan M, Pederson L, Kassem M, Westendorf J, Khosla S, et al. Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways. J Biol Chem. 2013;288:5398-406 pubmed publisher
Green J, Suzuki K, Cho B, Willison L, Palmer D, Allen C, et al. The sphingosine 1-phosphate receptor S1P? maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol. 2011;12:672-80 pubmed publisher
Long J, Fujiwara Y, Edwards J, Tannahill C, Tigyi G, Pyne S, et al. Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells. J Biol Chem. 2010;285:35957-66 pubmed publisher
Zhang G, Xu S, Qian Y, He P. Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules. Am J Physiol Heart Circ Physiol. 2010;299:H1494-504 pubmed publisher
Szczepaniak W, Pitt B, McVerry B. S1P2 receptor-dependent Rho-kinase activation mediates vasoconstriction in the murine pulmonary circulation induced by sphingosine 1-phosphate. Am J Physiol Lung Cell Mol Physiol. 2010;299:L137-45 pubmed publisher
Frias M, Lang U, Gerber Wicht C, James R. Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis. Cardiovasc Res. 2010;85:118-26 pubmed publisher
Li M, Sanchez T, Milne G, Morrow J, Hla T, Ferrer F. S1P/S1P2 signaling induces cyclooxygenase-2 expression in Wilms tumor. J Urol. 2009;181:1347-52 pubmed publisher
Li M, Sanchez T, Pappalardo A, Lynch K, Hla T, Ferrer F. Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. Mol Cancer Res. 2008;6:1649-56 pubmed publisher
Miller A, Alvarez S, Spiegel S, Lebman D. Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells. Mol Cell Biol. 2008;28:4142-51 pubmed publisher
product information
brand :
Tocris
master code :
2392
SKU :
2392/10
product name :
JTE 013
description :
S1P2 receptor antagonist
target :
Sphingosine-1-phosphate Receptor Antagonists
category :
Small Molecules
unit size :
10 mg
purity :
98%
observed molecular weight :
408.29
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Sphingosine-1-phosphate (S1P) receptor antagonist, highly selective for S1P2 (EDG-5). Inhibits S1P binding to human S1P2 receptors with an IC50 value of 17.6 nM. At concentrations up to 10 u M, displays 4.2% inhibition of S1P3 and does not antagonize S1P1. Enhances S1P-induced angiogenesis in vivo .
catalog number base :
2392
product keywords :
S1P2 receptor antagonists Receptors EDG5 Sphingosine-1-Phosphate JTE013 Sphingosine-1-phosphate Receptors 2392,
extended description :
S1P2 receptor antagonist
chemical name text :
1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide
formula :
C 17 H 19 N 7 OCl 2
formula text :
C17H19N7OCl2
cas num :
383150-41-2
2020 USD :
224
2021 USD :
233 USD
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK