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company name :
Tocris Bioscience
product type :
chemical
product name :
JTE 013
catalog :
2392/10
quantity :
10 mg
price :
292 USD
more info or order :
citations: 27
Reference
Matsushima Nishiwaki R, Yamada N, Fukuchi K, Kozawa O. Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2. PLoS ONE. 2018;13:e0209050 pubmed publisher
McMillin M, Frampton G, Grant S, Khan S, Diocares J, Petrescu A, et al. Bile Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Promotes Neuroinflammation during Hepatic Encephalopathy in Mice. Front Cell Neurosci. 2017;11:191 pubmed publisher
Wirrig C, McKean J, Wilson H, Nixon G. Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells. Biochem Pharmacol. 2016;115:43-50 pubmed publisher
Patmanathan S, Johnson S, Lai S, Panja Bernam S, Lopes V, Wei W, et al. Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. Sci Rep. 2016;6:25650 pubmed publisher
Chumanevich A, Wedman P, Oskeritzian C. Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2. Mediators Inflamm. 2016;2016:1503206 pubmed publisher
Kellner Y, Fricke S, Kramer S, Iobbi C, Wierenga C, Schwab M, et al. Nogo-A controls structural plasticity at dendritic spines by rapidly modulating actin dynamics. Hippocampus. 2016;26:816-31 pubmed publisher
Durham J, Dulmovits B, Cronk S, Sheets A, Herman I. Pericyte chemomechanics and the angiogenic switch: insights into the pathogenesis of proliferative diabetic retinopathy?. Invest Ophthalmol Vis Sci. 2015;56:3441-59 pubmed publisher
Gu Y, SHEA J, Slattum G, Firpo M, Alexander M, Mulvihill S, et al. Defective apical extrusion signaling contributes to aggressive tumor hallmarks. elife. 2015;4:e04069 pubmed publisher
Fernández Pisonero I, López J, Onecha E, Dueñas A, Maeso P, Crespo M, et al. Synergy between sphingosine 1-phosphate and lipopolysaccharide signaling promotes an inflammatory, angiogenic and osteogenic response in human aortic valve interstitial cells. PLoS ONE. 2014;9:e109081 pubmed publisher
Moriyama S, Takahashi N, Green J, Hori S, Kubo M, Cyster J, et al. Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers. J Exp Med. 2014;211:1297-305 pubmed publisher
Kempf A, Tews B, Arzt M, Weinmann O, Obermair F, Pernet V, et al. The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. PLoS Biol. 2014;12:e1001763 pubmed publisher
Shen Z, Liu C, Liu P, Zhao J, Xu W. Sphingosine 1-phosphate (S1P) promotes mitochondrial biogenesis in Hep G2 cells by activating Peroxisome proliferator-activated receptor ? coactivator 1? (PGC-1?). Cell Stress Chaperones. 2014;19:541-8 pubmed publisher
Beckham T, Cheng J, Lu P, Marrison S, Norris J, Liu X. Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. PLoS ONE. 2013;8:e76593 pubmed publisher
Beckham T, Cheng J, Lu P, Shao Y, Troyer D, Lance R, et al. Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling. Oncogenesis. 2013;2:e49 pubmed publisher
Stradner M, Gruber G, Angerer H, Huber V, Setznagl D, Kremser M, et al. Sphingosine 1-phosphate counteracts the effects of interleukin-1? in human chondrocytes. Arthritis Rheum. 2013;65:2113-22 pubmed publisher
Quint P, Ruan M, Pederson L, Kassem M, Westendorf J, Khosla S, et al. Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways. J Biol Chem. 2013;288:5398-406 pubmed publisher
Loh K, Leong W, Carlson M, Oskouian B, Kumar A, Fyrst H, et al. Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway. PLoS ONE. 2012;7:e37218 pubmed publisher
Lim M, Choi S, Cho Y, Yeon S, Kim E, Ahn D, et al. The role of sphingosine kinase 1/sphingosine-1-phosphate pathway in the myogenic tone of posterior cerebral arteries. PLoS ONE. 2012;7:e35177 pubmed publisher
Eisenhoffer G, Loftus P, Yoshigi M, Otsuna H, Chien C, Morcos P, et al. Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. Nature. 2012;484:546-9 pubmed publisher
Green J, Suzuki K, Cho B, Willison L, Palmer D, Allen C, et al. The sphingosine 1-phosphate receptor S1P? maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol. 2011;12:672-80 pubmed publisher
Long J, Fujiwara Y, Edwards J, Tannahill C, Tigyi G, Pyne S, et al. Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells. J Biol Chem. 2010;285:35957-66 pubmed publisher
Zhang G, Xu S, Qian Y, He P. Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules. Am J Physiol Heart Circ Physiol. 2010;299:H1494-504 pubmed publisher
Szczepaniak W, Pitt B, McVerry B. S1P2 receptor-dependent Rho-kinase activation mediates vasoconstriction in the murine pulmonary circulation induced by sphingosine 1-phosphate. Am J Physiol Lung Cell Mol Physiol. 2010;299:L137-45 pubmed publisher
Frias M, Lang U, Gerber Wicht C, James R. Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis. Cardiovasc Res. 2010;85:118-26 pubmed publisher
Li M, Sanchez T, Milne G, Morrow J, Hla T, Ferrer F. S1P/S1P2 signaling induces cyclooxygenase-2 expression in Wilms tumor. J Urol. 2009;181:1347-52 pubmed publisher
Li M, Sanchez T, Pappalardo A, Lynch K, Hla T, Ferrer F. Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. Mol Cancer Res. 2008;6:1649-56 pubmed publisher
Miller A, Alvarez S, Spiegel S, Lebman D. Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells. Mol Cell Biol. 2008;28:4142-51 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2392
SKU :
2392/10
product name :
JTE 013
description :
S1P2 receptor antagonist
target :
Sphingosine-1-phosphate Receptor Antagonists
unit size :
10 mg
category :
Small Molecules
purity :
98%
storage :
Store at +4°C
observed molecular weight :
408.29
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
JTE 013 is a sphingosine-1-phosphate (S1P) receptor antagonist, highly selective for S1P2 (EDG-5). Inhibits S1P binding to human S1P2 receptors with an IC50 value of 17.6 nM. At concentrations up to 10 u M, displays 4.2% inhibition of S1P3 and does not antagonize S1P1. Enhances S1P-induced angiogenesis in vivo .
product keywords :
S1P2 receptor antagonists Receptors EDG5 Sphingosine-1-Phosphate JTE013 Sphingosine-1-phosphate Receptors 2392,
extended description :
S1P2 receptor antagonist
chemical name text :
1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide
formula :
C17H19N7OCl2
formula text :
C17H19N7OCl2
cas num :
383150-41-2
USD :
289
USD 2025 :
292 USD
product details :
S1P2 receptor antagonist
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK