product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Astressin 2B
catalog :
2391/500U
quantity :
500 ug
price :
555 USD
more info or order :
citations: 8
Reference
Li N, Yang Z, Li Q, Yu Z, Chen X, Li J, et al. Ablation of somatostatin cells leads to impaired pancreatic islet function and neonatal death in rodents. Cell Death Dis. 2018;9:682 pubmed publisher
Martinon D, Dabrowska J. Corticotropin-Releasing Factor Receptors Modulate Oxytocin Release in the Dorsolateral Bed Nucleus of the Stria Terminalis (BNST) in Male Rats. Front Neurosci. 2018;12:183 pubmed publisher
Rodriguez J, Huerta Yepez S, Law I, Baay Guzman G, Tirado Rodriguez B, Hoffman J, et al. Diminished expression of CRHR2 in human colon cancer promotes tumor growth and EMT via persistent IL-6/Stat3 signaling. Cell Mol Gastroenterol Hepatol. 2015;1:610-630 pubmed
Tran L, Schulkin J, Greenwood Van Meerveld B. Importance of CRF receptor-mediated mechanisms of the bed nucleus of the stria terminalis in the processing of anxiety and pain. Neuropsychopharmacology. 2014;39:2633-45 pubmed publisher
Boyson C, Holly E, Shimamoto A, Albrechet Souza L, Weiner L, DeBold J, et al. Social stress and CRF-dopamine interactions in the VTA: role in long-term escalation of cocaine self-administration. J Neurosci. 2014;34:6659-67 pubmed publisher
Abdelhamid R, Kovács K, Pasley J, Nunez M, Larson A. Forced swim-induced musculoskeletal hyperalgesia is mediated by CRF2 receptors but not by TRPV1 receptors. Neuropharmacology. 2013;72:29-37 pubmed publisher
Silberman Y, Winder D. Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala. Neuropharmacology. 2013;70:316-23 pubmed publisher
Kash T, Nobis W, Matthews R, Winder D. Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process. J Neurosci. 2008;28:13856-65 pubmed publisher
product information
brand :
Tocris, a Bio-Techne Brand
catalog number base :
2391
SKU :
2391/500U
product name :
Astressin 2B
Description :
Selective CRF2 antagonist
target :
CRF2 Receptor Antagonists
category :
Peptides
unit size :
500 ug
purity :
95%
observed molecular weight :
4041.69
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=peptides
details of functionality :
Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist (IC50 values are 1.3 and 500 nM for CRF2 and CRF1 respectively). Antagonizes CRF2-mediated inhibition of gastric emptying.
extended description :
Selective CRF2 antagonist
formula :
C 183 H 307 N 49 O 53
formula text :
C183H307N49O53
cas num :
681260-70-8
USD :
555 USD
product details :
Selective CRF2 antagonist
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK