LY 320135 | Tocris Bioscience 2387 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LY 320135

catalog :

2387

quantity :

10 mg (also 50 mg)

price :

157 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Stanley C, Hind W, Tufarelli C, O Sullivan S. Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation. Cardiovasc Res. 2015;107:568-78 pubmed publisher
Vicente Sánchez A, Sánchez Blázquez P, Rodríguez Muñoz M, Garzón J. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity. Mol Brain. 2013;6:42 pubmed publisher
Morgan N, Stanford I, Woodhall G. Modulation of network oscillatory activity and GABAergic synaptic transmission by CB1 cannabinoid receptors in the rat medial entorhinal cortex. Neural Plast. 2008;2008:808564 pubmed publisher
Czesnik D, Schild D, Kuduz J, Manzini I. Cannabinoid action in the olfactory epithelium. Proc Natl Acad Sci U S A. 2007;104:2967-72 pubmed

product information

brand :

Tocris

master code :

2387

SKU :

2387/10

product name :

LY 320135

description :

Selective CB1 inverse agonist

target :

Cannabinoid R1 / CB1 Inverse Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

383.4

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent CB1 receptor antagonist/inverse agonist (Ki = 141 nM) with greater than 70-fold selectivity over CB2 receptors (Ki 10 u M). Structurally dissimilar from SR 141716A and AM 251. Shows weak binding to both 5-HT2 (Ki = 6.4 u M) and muscarinic receptors (Ki = 2.1 u M).

catalog number base :

2387

product keywords :

Selective CB1 receptor antagonists inverse agonists cannabinoids Receptors LY320135 cb1r CB1 Receptors 2387,

extended description :

Selective CB1 inverse agonist

chemical name text :

4-[[6-Methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]benzonitrile

formula :

C 24 H 17 NO 4

formula text :

C24H17NO4

cas num :

176977-56-3

2020 USD :

152

2021 USD :

157 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage