Fenobam | Tocris Bioscience 2386 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Fenobam

catalog :

2386

quantity :

10 mg (also 50 mg)

price :

133 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Crock L, Stemler K, Song D, Abbosh P, Vogt S, Qiu C, et al. Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception. Mol Pain. 2012;8:20 pubmed publisher

product information

brand :

Tocris

master code :

2386

SKU :

2386/10

product name :

Fenobam

description :

Potent and selective mGlu5 negative allosteric modulator (NAM)

target :

Group I mGluR Modulators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

266.69

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective non-competitive mGlu5 negative allosteric modulator (NAM) that also displays inverse agonist properties; blocks mGlu5 constitutive activity in vitro (IC50 = 87 nM). Acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors respectively. Displays anxiolytic activity following oral administration in vivo ; also exhibits analgesic properties.

catalog number base :

2386

product keywords :

Potent selective mGlu5 antagonist mGluR5 antagonists Group I Receptors Glutamate Metabotropic Glutamate (Metabotropic) Group I Receptors 2386,

extended description :

Potent and selective mGlu5 negative allosteric modulator (NAM)

chemical name text :

N-(3-Chlorophenyl)-N -(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea

formula :

C 11 H 11 N 4 O 2 Cl

formula text :

C11H11N4O2Cl

cas num :

57653-26-6

2020 USD :

129

2021 USD :

133 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage