Fenobam | Tocris Bioscience 2386/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Fenobam

catalog :

2386/10

quantity :

10 mg (also 50 mg)

price :

168 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Liao S, Ruiz Y, Gulzar H, Yelskaya Z, Ait Taouit L, Houssou M, et al. Osteosarcoma cell proliferation and survival requires mGluR5 receptor activity and is blocked by Riluzole. PLoS ONE. 2017;12:e0171256 pubmed publisher
Crock L, Stemler K, Song D, Abbosh P, Vogt S, Qiu C, et al. Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception. Mol Pain. 2012;8:20 pubmed publisher

image

image 1 :

Cat.No. 2386 - Fenobam C11H11N4O2Cl CAS No. 57653-26-6

product information

brand :

Tocris

catalog number base :

2386

SKU :

2386/10

product name :

Fenobam

units size :

10 mg (also 50 mg)

description :

Potent and selective mGlu5 negative allosteric modulator (NAM)

target :

Group I mGluR Modulators

category :

Small Molecules

purity :

98%

observed molecular weight :

266.69

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Fenobam is a potent and selective non-competitive mGlu5 negative allosteric modulator (NAM) that also displays inverse agonist properties; blocks mGlu5 constitutive activity in vitro (IC50 = 87 nM). Acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors respectively. Displays anxiolytic activity following oral administration in vivo ; also exhibits analgesic properties.

top caption :

Potent and selective mGlu5 negative allosteric modulator (NAM)

extended description :

Potent and selective mGlu5 negative allosteric modulator (NAM)

chemical name text :

N-(3-Chlorophenyl)-N -(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea

formula :

C11H11N4O2Cl

formula text :

C11H11N4O2Cl

cas num :

57653-26-6

USD :

168 USD

product details :

Potent and selective mGlu5 negative allosteric modulator (NAM)

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage