AMN 082 dihydrochloride | Tocris Bioscience 2385 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AMN 082 dihydrochloride

catalog :

2385

quantity :

10 mg (also 50 mg)

price :

124 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Shao L, Liu Y, Xiao J, Wang Q, Liu F, Ding J. Activating metabotropic glutamate receptor‑7 attenuates visceral hypersensitivity in neonatal maternally separated rats. Int J Mol Med. 2019;43:761-770 pubmed publisher
Jantas D, Lech T, Gołda S, Pilc A, Lasoń W. New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection. Neuropharmacology. 2018;141:223-237 pubmed publisher
Broadstock M, Austin P, Betts M, Duty S. Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata. Br J Pharmacol. 2012;165:1034-45 pubmed publisher

product information

brand :

Tocris

master code :

2385

SKU :

2385/10

product name :

AMN 082 dihydrochloride

description :

Selective mGlu7 agonist

target :

Group III mGluR Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

465.45

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

The first selective mGlu7 agonist. Potently inhibits cAMP accumulation and stimulates GTP S binding in recombinant cells and on membranes expressing mGlu7 (EC50 = 64 - 290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 u M. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats. . View important information regarding the usage of >AMN 082 dihydrochloride .

catalog number base :

2385

product keywords :

selective mGlu7 mGluR7 agonists mGlur Group III Receptors Glutamate Metabotropic AMN082 dihydrochloride Glutamate (Metabotropic) Group III Receptors 2385,

extended description :

Selective mGlu7 agonist

chemical name text :

N,N -Bis(diphenylmethyl)-1,2-ethanediamine dihydrochloride

formula :

C 28 H 28 N 2 .2HCl

formula text :

C28H28N2.2HCl

cas num :

97075-46-2

2020 USD :

120

2021 USD :

124 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage